Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C29H43NO2S |
Molecular Weight | 469.722 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCS[C@H](C(=O)NC1=CC(C)=C(O)C(C)=C1C)C2=CC=CC=C2
InChI
InChIKey=ZXEIEKDGPVTZLD-NDEPHWFRSA-N
InChI=1S/C29H43NO2S/c1-5-6-7-8-9-10-11-12-13-17-20-33-28(25-18-15-14-16-19-25)29(32)30-26-21-22(2)27(31)24(4)23(26)3/h14-16,18-19,21,28,31H,5-13,17,20H2,1-4H3,(H,30,32)/t28-/m0/s1
Molecular Formula | C29H43NO2S |
Molecular Weight | 469.722 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/18466422Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/11137714 | https://www.ncbi.nlm.nih.gov/pubmed/12735237 | http://adisinsight.springer.com/drugs/800011031
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18466422
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/11137714 | https://www.ncbi.nlm.nih.gov/pubmed/12735237 | http://adisinsight.springer.com/drugs/800011031
Eflucimibe is a new and potent Acyl coenzyme A:cholesterol acyltransferases inhibitor. Eflucimibe effectively decreased plasma cholesterol in cholesterol-fed animals. In animal models, drug restores normolipodemia in endogenous hypercholesterolemic rabbits and prevents the progression of atherosclerosis by decreasing the number of macrophages in the foam cells. Eflucimibe has been in phase II clinical trials for the treatment of atherosclerosis and hyperlipidemia. However, this research has been discontinued.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11137714
Curator's Comment: https://www.google.tl/patents/US5990173
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2782 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18466422 |
39.0 nM [IC50] | ||
Target ID: CHEMBL4465 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18466422 |
110.0 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11791003
Rabbit: 8 mg/kg per day (during 24 weeks)
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17031267
The addition of increasing concentrations of F12511 (10 to 10 mol/L) failed to modify the level of eNOS protein expressed in control bovine aortic endothelial cells (BAEC). F12511 (10 mol/L) failed to modify the expression of CD40L and PECAM in control and TNF-alpha-incubated BAEC.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:06:09 GMT 2023
by
admin
on
Fri Dec 15 16:06:09 GMT 2023
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Record UNII |
3DK1X2C37M
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Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29703
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9804740
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3DK1X2C37M
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7802
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DTXSID70174085
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C75995
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CHEMBL1908306
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202340-45-2
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300000034238
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ACTIVE MOIETY |
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