U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Fe.O4S.7H2O
Molecular Weight 278.015
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERROUS SULFATE

SMILES

O.O.O.O.O.O.O.[Fe++].[O-]S([O-])(=O)=O

InChI

InChIKey=SURQXAFEQWPFPV-UHFFFAOYSA-L
InChI=1S/Fe.H2O4S.7H2O/c;1-5(2,3)4;;;;;;;/h;(H2,1,2,3,4);7*1H2/q+2;;;;;;;;/p-2

HIDE SMILES / InChI
Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en

Iron(II) gluconate (also known as a ferrous gluconate) is used in the treatment of hypochromic anemia. The real problem of iron therapy is not the theoretical utilization of iron, or the reticulocyte response, or even the daily increase of hemoglobin. These are important only as they indicate the return of the patients' blood to normal in a reasonably short time without undue inconvenience. Most patients suffering from hypochromic anemia respond well to most forms of iron when administered in adequate dosage. For the patients who cannot tolerate the usual iron compounds, it is important to have a medication which is effective and which causes minimum disturbance. Ferrous gluconate is such a medicament.

Originator

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Not Provided
504
Unknown

Approved Use

Unknown
Palliative
Not Provided
504
Unknown

Approved Use

Unknown
Primary
Approved
8429
Ferro Sanol Duodenal

Approved Use

Ferro Sanol is an iron substitute in case of latent or manifest iron deficiency with and without development of anaemia.
PubMed

PubMed

TitleDatePubMed
FERROUS IODIDE AND LINOLEIC ACID IN VITAMIN A DEFICIENCY. A REPLY TO CERTAIN CRITICISMS.
1932 Nov 11
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA.
1937 Jul
[Ferrous lactate as an oral iron preparation for therapeutic use].
1954 Nov 27
Clinical appraisal of drugs with special reference to a new chelate hematinic.
1957 Jul 11
[FERROUS ASPARTATE IN THERAPY].
1964 Jan 1
[Historical notes on the therapy of depression].
1986 Nov 22
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.
1997 Oct
Decreased treatment failure rates following duodenal release ferrous glycine sulfate in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis.
2007
Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice.
2009
Bioleaching of heavy metals from sewage sludge by indigenous iron-oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources: a comparative study.
2009 Nov 15
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia.
2010 Dec
Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis.
2011 Jun 10
Tolerability of different oral iron supplements: a systematic review.
2013 Apr
Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.
2013 Jul
A practical and successful desensitization protocol for immediate hypersensitivity reactions to iron salts.
2014
Patents

Patents

CN105565963
36
US20020127665
36
US2009028810
36
US20150202224
36
US2877253
36
US3091626
36
US5534268
36
US6407138
36
US8080520
36
US8802114
36

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:28:17 GMT 2023
Edited
by admin
on Fri Dec 15 15:28:17 GMT 2023
Record UNII
39R4TAN1VT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROUS SULFATE
FCC   INCI   MART.   ORANGE BOOK   USP   USP-RS   VANDF   WHO-IP  
INCI  
Official Name English
IRON(II) SULPHATE (1:1), HEPTAHYDRATE
Common Name English
FERRUM SULPHURICUM
HPUS  
Common Name English
FEOSOL
Brand Name English
FERROUS SULFATE [INCI]
Common Name English
HAEMOFORT
Brand Name English
FERROUS SULFATE HEPTAHYDRATE [WHO-IP]
Common Name English
FERRUM SULPHURICUM [HPUS]
Common Name English
FERROUS SULFATE HEPTAHYDRATE [MI]
Common Name English
FERROUS SULFATE, EXSICCATED [WHO-IP]
Common Name English
FERROUS SULFATE [MART.]
Common Name English
IRON (AS FERROUS SULFATE) [VANDF]
Common Name English
SULFURIC ACID, IRON(2+) SALT (1:1), HEPTAHYDRATE
Common Name English
FERROUS SULFATE [USP MONOGRAPH]
Common Name English
FERROUS SULFATE [ORANGE BOOK]
Common Name English
FERROUS SULFATE COMPONENT OF FOLVRON
Common Name English
Iron(2+) sulfate (1:1) heptahydrate
Common Name English
FESOFOR
Brand Name English
FERROUS SULFATE HYDRATE
JAN  
Common Name English
FERO-GRADUMET
Brand Name English
FERROUS SULFATE [VANDF]
Common Name English
FERROUS SULFATE HEPTAHYDRATE [EP MONOGRAPH]
Common Name English
MOL-IRON
Brand Name English
SULFERROUS
Brand Name English
FERROUS SULPHATE HEPTAHYDRATE
Common Name English
FERROUS SULFATE [USP-RS]
Common Name English
FERROUS SULFATE HEPTAHYDRATE
EP   MI   WHO-DD   WHO-IP  
Common Name English
FER-IN-SOL
Brand Name English
Ferrous sulfate heptahydrate [WHO-DD]
Common Name English
PRESFERSUL
Brand Name English
FOLVRON COMPONENT FERROUS SULFATE
Common Name English
IRONATE
Brand Name English
COPPERAS
Brand Name English
FERROUS SULPHATE
Common Name English
GREEN VITRIOL
Common Name English
FERROUS SULFATE [FCC]
Common Name English
IRON(II) SULPHATE HEPTAHYDRATE
Systematic Name English
FERROUS SULFATE HYDRATE [JAN]
Common Name English
IRON(2+) SULPHATE (1:1) HEPTAHYDRATE
Common Name English
IRON VITRIOL
Common Name English
FERROUS SULFATE [WHO-IP]
Common Name English
FEOSPAN
Brand Name English
FERROSI SULFAS [WHO-IP LATIN]
Common Name English
IRON(II) SULFATE (1:1), HEPTAHYDRATE
Common Name English
IRON(II) SULFATE HEPTAHYDRATE
Systematic Name English
FERROUS II SULFATE HEPTAHYDRATE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 50502
Created by admin on Fri Dec 15 15:28:17 GMT 2023 , Edited by admin on Fri Dec 15 15:28:17 GMT 2023
WHO-ATC B03AD03
Created by admin on Fri Dec 15 15:28:17 GMT 2023 , Edited by admin on Fri Dec 15 15:28:17 GMT 2023
CFR 21 CFR 184.1315
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LIVERTOX 407
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WHO-VATC QB03AA07
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WHO-ATC B03AA07
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WHO-VATC QB03AD03
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Code System Code Type Description
RS_ITEM_NUM
1270355
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PRIMARY
EPA CompTox
DTXSID9040344
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PRIMARY
EVMPD
SUB126949
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PRIMARY
CHEBI
75832
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PRIMARY
CAS
7782-63-0
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PRIMARY
PUBCHEM
62662
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PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
FERROUS SULFATE
Created by admin on Fri Dec 15 15:28:17 GMT 2023 , Edited by admin on Fri Dec 15 15:28:17 GMT 2023
PRIMARY Description: Exsiccated Ferrous sulfate is a greyish white powder; Ferrous sulfate heptahydrate has pale blue-green prisms or isa pale green, crystalline powder; both forms are odourless.Solubility: Exsiccated Ferrous sulfate is slowly but almost completely soluble in carbon-dioxide-free water R; practically insolublein ethanol (~750 g/l) TS. Ferrous sulfate heptahydrate is freely soluble in water; very soluble in boiling water; practically insolublein ethanol (~750 g/l) TS.Category. Haemopoietic (iron-deficiency anaemia).Storage: Ferrous sulfate should be kept in a well-closed container.Labelling: The designation on the container of Ferrous sulfate should state whether the substance is in the exsiccated form or isthe heptahydrate.
NCI_THESAURUS
C29049
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PRIMARY
DRUG CENTRAL
4528
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PRIMARY
EVMPD
SUB21826
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PRIMARY
SMS_ID
100000087595
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PRIMARY
MESH
C020748
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PRIMARY
DAILYMED
39R4TAN1VT
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PRIMARY
ChEMBL
CHEMBL1200830
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PRIMARY
CHEBI
75836
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PRIMARY
FDA UNII
39R4TAN1VT
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PRIMARY
RXCUI
24947
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PRIMARY RxNorm
WIKIPEDIA
Ferrous sulfate
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PRIMARY
EVMPD
SUB13877MIG
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PRIMARY
MERCK INDEX
m5354
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PRIMARY Merck Index
DRUG BANK
DBSALT002666
Created by admin on Fri Dec 15 15:28:17 GMT 2023 , Edited by admin on Fri Dec 15 15:28:17 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 15:28:17 GMT 2023 , Edited by admin on Fri Dec 15 15:28:17 GMT 2023
CONCEPT Dietary Supplement
Related Record Type Details
Structure of FERROUS SULFATE ANHYDROUS
ANHYDROUS->SOLVATE
Structure of FERROUS CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of FERROUS CATION
ACTIVE MOIETY
NIH
NCATS
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ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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