U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C14H16ClNO
Molecular Weight 249.736
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BEXLOSTERIDE

SMILES

[H][C@@]12CCC3=CC(Cl)=CC=C3[C@@]1([H])CCC(=O)N2C

InChI

InChIKey=WQBIOEFDDDEARX-CHWSQXEVSA-N
InChI=1S/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m1/s1

HIDE SMILES / InChI

Molecular Formula C14H16ClNO
Molecular Weight 249.736
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

LY 300502 is now called bexlosteride was developed as an inhibitor of the human-specific type I-selective steroid 5alpha-reductase. This drug was studied for patients with prostate cancer, however, has never been marketed.

Approval Year

PubMed

PubMed

TitleDatePubMed
Responses of LNCaP prostatic adenocarcinoma cell cultures to LY300502, a benzoquinolinone human type I 5alpha-reductase inhibitor.
1996
Three- and four-dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2C9 inhibitors.
2000 Aug
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:31:23 GMT 2023
Edited
by admin
on Sat Dec 16 16:31:23 GMT 2023
Record UNII
36X732P4P0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BEXLOSTERIDE
INN   USAN  
USAN   INN  
Official Name English
LY-300502
Code English
LY-191704
Code English
(4aR,10bR)-8-Chloro-1,4,4a,5,6,10b-hexahydro-4-methylbenzo[f]quinolin-3(2H)-one
Common Name English
bexlosteride [INN]
Common Name English
BENZO(F)QUINOLIN-3(2H)-ONE, 8-CHLORO-1,4,4A,5,6,10B-HEXAHYDRO-4-METHYL-, (4AR-TRANS)
Common Name English
LY300502
Code English
BEXLOSTERIDE [USAN]
Common Name English
Code System Code Type Description
FDA UNII
36X732P4P0
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
EPA CompTox
DTXSID00869972
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
CAS
148905-78-6
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
PUBCHEM
166562
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
WIKIPEDIA
BEXLOSTERIDE
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
SMS_ID
300000034098
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
INN
7847
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL24955
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
USAN
KK-56
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
NCI_THESAURUS
C166644
Created by admin on Sat Dec 16 16:31:23 GMT 2023 , Edited by admin on Sat Dec 16 16:31:23 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY