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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H27ClN2.C4H4O4
Molecular Weight 470.988
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ZICRONAPINE FUMARATE

SMILES

OC(=O)\C=C\C(O)=O.CN1CCN(CC1(C)C)[C@@H]2C[C@H](C3=C2C=C(Cl)C=C3)C4=CC=CC=C4

InChI

InChIKey=PSDXTSHOYHAMTE-VFHZDWIZSA-N
InChI=1S/C22H27ClN2.C4H4O4/c1-22(2)15-25(12-11-24(22)3)21-14-19(16-7-5-4-6-8-16)18-10-9-17(23)13-20(18)21;5-3(6)1-2-4(7)8/h4-10,13,19,21H,11-12,14-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t19-,21+;/m0./s1

HIDE SMILES / InChI
Molecular Formula C22H27ClN2
Molecular Weight 354.916
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Zicronapine (formerly known as Lu 31-130), an oral antipsychotic that was studied for the treatment of schizophrenia. The drug was used in a phase III clinical trial.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
A review of the pharmacology, efficacy and tolerability of recently approved and upcoming oral antipsychotics: an evidence-based medicine approach.
2013 Nov
Patents

Patents

20060281758
2
20060281759
3
20080153847
2
20080153848
2
JP2011201924A
2

Sample Use Guides

In Vivo Use Guide
7.5 mg/day
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:02:26 UTC 2023
Edited
by admin
on Fri Dec 15 16:02:26 UTC 2023
Record UNII
354Q3TY534
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZICRONAPINE FUMARATE
Common Name English
PIPERAZINE, 4-((1R,3S)-6-CHLORO-2,3-DIHYDRO-3-PHENYL-1H-INDEN-1-YL)-1,2,2-TRIMETHYL-, (2E)-2-BUTENEDIOATE (1:1)
Systematic Name English
(-)-TRANS-4-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE HYDROGEN FUMARATE
Common Name English
Code System Code Type Description
SMS_ID
300000013054
Created by admin on Fri Dec 15 16:02:26 UTC 2023 , Edited by admin on Fri Dec 15 16:02:26 UTC 2023
PRIMARY
FDA UNII
354Q3TY534
Created by admin on Fri Dec 15 16:02:26 UTC 2023 , Edited by admin on Fri Dec 15 16:02:26 UTC 2023
PRIMARY
PUBCHEM
67266632
Created by admin on Fri Dec 15 16:02:26 UTC 2023 , Edited by admin on Fri Dec 15 16:02:26 UTC 2023
PRIMARY
CAS
170381-17-6
Created by admin on Fri Dec 15 16:02:26 UTC 2023 , Edited by admin on Fri Dec 15 16:02:26 UTC 2023
PRIMARY
Related Record Type Details
Structure of ZICRONAPINE
PARENT -> SALT/SOLVATE
Structure of Fumaric acid
PARENT -> SALT/SOLVATE
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