Lecankitug

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:38:18 GMT 2025` Edited by `admin` on `Wed Apr 02 20:38:18 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	34KYN5U7P7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV1-46*01 (83.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (215) (119-216), hinge 1-15 (217

Preferred Name

English

Lecankitug

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens IL17A (interleukin 17A, IL-17A) and IL17F (interleukin 17F, IL-17F)], humanized monoclonal antibody (lecankitug)

Common Name

English

Immunoglobulin G1, anti-(human interleukin 17A/interleukin 17F) (human-Mus musculus monoclonal LZM012 ?1-chain), disulfide with human-Mus musculus monoclonal LZM012 ?-chain, dimer

Common Name

English

lecankitug [INN]

Common Name

English

Code System Code Type Description

INN

13350

Created by admin on Wed Apr 02 20:38:18 GMT 2025 , Edited by admin on Wed Apr 02 20:38:18 GMT 2025

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CAS

2923284-76-6

Created by admin on Wed Apr 02 20:38:18 GMT 2025 , Edited by admin on Wed Apr 02 20:38:18 GMT 2025

PRIMARY

FDA UNII

34KYN5U7P7

Created by admin on Wed Apr 02 20:38:18 GMT 2025 , Edited by admin on Wed Apr 02 20:38:18 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_219
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_221	3_219
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					R44E6C7B6J

INTERLEUKIN-17A

TARGET->LIGAND

Amount:

Related Record Type Details


					34KYN5U7P7

Lecankitug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL