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Description
Curator's Comment: Description was created based on several sources, including https://www.brambleberry.com/sodium-lactate-p5127.aspx | http://www.fbcindustries.com/Sodium_Lactate.aspx

Sodium lactate is primarily indicated as a source of bicarbonate for prevention or control of mild to moderate metabolic acidosis in patients with restricted oral intake whose oxidative processes are not seriously impaired. Sodium Lactate is most commonly associated with an E number of “E325” Sodium Lactate blends are commonly used in meat and poultry products to extend shelf life and increase food safety. They have a broad antimicrobial action and are effective at inhibiting most spoilage and pathogenic bacteria. In addition sodium lactate is used in cosmetics as a humectant, providing moisture.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SODIUM LACTATE IN PLASTIC CONTAINER

Approved Use

Sodium Lactate Injection, USP 50 mEq (5 mEq/mL), is primarily indicated, after dilution, as a source of bicarbonate for prevention or control of mild to moderate metabolic acidosis in patients with restricted oral intake whose oxidative processes are not seriously impaired. It is not intended nor effective for correcting severe acidotic states which require immediate restoration of plasma bicarbonate levels. Sodium lactate has no advantage over sodium bicarbonate and may be detrimental in the management of lactic acidosis

Launch Date

1984
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
20.2 μg/mL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTATE ION, L- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.03 mg/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTIC ACID, D- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
53.35 mg × h/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTATE ION, L- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.44 mg × h/dL
39.76 mmol other, intravenous
dose: 39.76 mmol
route of administration: Intravenous
experiment type: OTHER
co-administered:
LACTIC ACID, D- plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Lactate- and isoproterenol-induced panic attacks in panic disorder patients and controls.
1988 Feb
Cloning of a lactate dehydrogenase gene from Clostridium acetobutylicum B643 and expression in Escherichia coli.
1990 Dec
Malignant ventricular tachycardia during propafenone treatment in a child with junctional automatic tachycardia: effectiveness of intravenous molar sodium lactate.
1991 May
Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder.
2007 Jan 15
Patents

Sample Use Guides

Sodium Lactate Injection, USP 50 mEq (5 mEq/mL) is administered intravenously only after addition to a larger volume of fluid. The amount of sodium ion and lactate ion to be added to larger volume intravenous fluids should be determined in accordance with the electrolyte requirements of each individual patient. All or part of the content(s) of one (50 mEq in 10 mL) or more vial containers may be added to other intravenous solutions to provide any desired number of milliequivalents of lactate anion (with the same number of milliequivalents of Na+ ). The contents of one container (50 mEq in 10 mL) added to 290 mL of a nonelectrolyte solution or of sterile water for injection will provide 300 mL of an approximately isotonic (1/6 molar) concentration of sodium lactate (1.9%), containing 167 mEq/liter each of Na+ and lactate anion
Route of Administration: Intravenous
10 mM sodium lactate inhibits activated T cell motility
Substance Class Mixture
Created
by admin
on Fri Dec 15 16:10:23 GMT 2023
Edited
by admin
on Fri Dec 15 16:10:23 GMT 2023
Record UNII
33X04XA5AT
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
Lactic acid
EP   FHFI   GREEN BOOK   HSDB   II   INCI   ORANGE BOOK   USP   VANDF   WHO-DD  
INCI  
Preferred Name English
LACTIC ACID, UNSPECIFIED FORM
Common Name English
LACTIC ACID [VANDF]
Common Name English
LACTIC ACID [II]
Common Name English
LACTIC ACID [EP MONOGRAPH]
Common Name English
LACTIC ACID [ORANGE BOOK]
Common Name English
LACTIC ACID [FHFI]
Common Name English
LACTIC ACID,BUFFERED [VANDF]
Common Name English
L-LACTIC ACID OR DL-LACTIC ACID
Common Name English
LACTIC ACID [INCI]
Common Name English
Lactic acid [WHO-DD]
Common Name English
FEMA NO. 2611
Code English
LACTIC ACID [USP-RS]
Common Name English
L-LACTIC ACID/L-LACTIC ACID LACTATE OR DL-LACTIC ACID/DL-LACTIC ACID LACTATE
Common Name English
LACTIC ACID [GREEN BOOK]
Common Name English
LACTIC ACID,BUFFERED
VANDF  
Common Name English
LACTIC ACID [HSDB]
Common Name English
LACTIC ACID [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION LACTIC ACID
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
FDA ORPHAN DRUG 122098
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
WHO-ATC A07FA01
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
WHO-VATC QP53AG02
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
DSLD 1598 (Number of products:7)
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
WHO-ATC G01AD01
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
CFR 21 CFR 184.1061
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
WHO-VATC QG01AD01
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
Code System Code Type Description
JECFA MONOGRAPH
781
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
CHEBI
28358
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
DAILYMED
33X04XA5AT
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
RXCUI
114202
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
ALTERNATIVE
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
CONCEPT Industrial Aid
NCI_THESAURUS
C76926
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
RXCUI
28393
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200559
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
MESH
D019344
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
SMS_ID
100000087110
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
DRUG CENTRAL
1533
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
WIKIPEDIA
LACTIC ACID
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
CHEBI
42111
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
DRUG BANK
DB04398
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
FDA UNII
33X04XA5AT
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
LACTMED
Lactic Acid, Citric Acid, and Potassium Bitartrate
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
CHEBI
78320
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
EVMPD
SUB14307MIG
Created by admin on Fri Dec 15 16:10:23 GMT 2023 , Edited by admin on Fri Dec 15 16:10:23 GMT 2023
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
ACTIVE MOIETY
Definition References