Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C9H13NO3.ClH |
| Molecular Weight | 219.665 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CNCC(O)C1=CC(O)=C(O)C=C1
InChI
InChIKey=ATADHKWKHYVBTJ-UHFFFAOYSA-N
InChI=1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C9H13NO3 |
| Molecular Weight | 183.2044 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Racepinephrine or racemic epinephrine is a mixture of levo and dextro isomers of epinephrine act as a nonselective agonist at adrenergic receptors. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, shortness of breath. Inhaled racepinephrine became available in September 2012 as a nonprescription treatment for bronchospasm based on a 1986 US Food and Drug Administration rule. Besides, racemic epinephrine relieves respiratory distress in hospitalized infants with bronchiolitis and is safe but does not abbreviate hospital stay. Morbidity associated with bronchiolitis as identified by parents persists for at least one week after hospital discharge in most infants.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2331074 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | Unknown Approved UseFor temporary relief of mild symptoms of intermittent asthma: wheezing, tightness of chest, shortness of breath |
|||
| Palliative | Unknown Approved UseUnknown |
Doses
| Dose | Population | Adverse events |
|---|---|---|
50 mg single, oral Overdose |
unknown, 2 years n = 1 Health Status: unknown Age Group: 2 years Sex: M Population Size: 1 Sources: |
Disc. AE: Hypertension, Tachycardia... AEs leading to discontinuation/dose reduction: Hypertension (5.4%) Sources: Tachycardia (5.4%) |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Hypertension | 5.4% Disc. AE |
50 mg single, oral Overdose |
unknown, 2 years n = 1 Health Status: unknown Age Group: 2 years Sex: M Population Size: 1 Sources: |
| Tachycardia | 5.4% Disc. AE |
50 mg single, oral Overdose |
unknown, 2 years n = 1 Health Status: unknown Age Group: 2 years Sex: M Population Size: 1 Sources: |
PubMed
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| [Surface architectonics and cytoskeleton of erythrocytes and their modulation by adrenergic agents in patients with bronchial asthma]. | 2004 |
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| Cytotoxic effects of gingival retraction cords on human gingival fibroblasts in vitro. | 2004 Apr |
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| Stereospecificity of horseradish peroxidase. | 2004 Dec |
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| Cardiovascular responses of Chinook salmon (Oncorhynchus tshawytscha) during rapid anaesthetic induction and recovery. | 2004 Feb |
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| Extravasation of blood-borne immunoglobulin G through blood-brain barrier during adrenaline-induced transient hypertension in the rat. | 2004 Jun |
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| MAPK-dependent regulation of IL-1- and beta-adrenoreceptor-induced inflammatory cytokine production from mast cells: implications for the stress response. | 2004 Sep 21 |
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|
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| Strategies for enantioseparations of catecholamines and structurally related compounds by capillary zone electrophoresis using sulfated beta-cyclodextrins as chiral selectors. | 2006 Sep |
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|
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|
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|
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|
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|
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|
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|
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| Calcium deficiency in the early stages after weaning is associated with the enhancement of a low level of adrenaline-stimulated lipolysis and reduction of adiponectin release in isolated rat mesenteric adipocytes. | 2010 Jul |
|
| Intraoperative chemotherapy with cisplatin and epinephrine after cytoreductive surgery in patients with recurrent ovarian cancer: a phase I study. | 2010 Mar |
|
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|
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Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 23:53:54 UTC 2023
by
admin
on
Wed Jul 05 23:53:54 UTC 2023
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| Record UNII |
336096P2WE
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| Record Status |
Validated (UNII)
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| Record Version |
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C319
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CFR |
21 CFR 341.16
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M4944
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C73826
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DTXSID9057717
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329-63-5
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SUB33967
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ENANTIOMER -> RACEMATE | |||
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PARENT -> SALT/SOLVATE | |||
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ENANTIOMER -> RACEMATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |