Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H7NO2S |
| Molecular Weight | 133.169 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(=O)(=O)CCC#N
InChI
InChIKey=LQFRYKBDZNPJSW-UHFFFAOYSA-N
InChI=1S/C4H7NO2S/c1-8(6,7)4-2-3-5/h2,4H2,1H3
| Molecular Formula | C4H7NO2S |
| Molecular Weight | 133.169 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Dapansutrile is an inhibitor of the NLRP3 inflammasome, developed by Olatec Therapeutics LLC. NLRP3 inflammasome is a driver of sterile inflammation in response to myocardial ischemia-reperfusion and other inflammatory conditions. Dapansutrile limits infarct size and prevents left ventricular systolic dysfunction in the mouse model of ischemia-reperfusion injury and suppresses joint inflammation in the mouse model of acute arthritis. Dapansutrile demonstrated a clinical and inflammatory cytokine response in a clinical trial for the treatment of acute gout and is being investigated for the treatment of Systolic Heart Failure and Schnitzler Syndrome.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:45:23 GMT 2023
by
admin
on
Sat Dec 16 08:45:23 GMT 2023
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| Record UNII |
2Z03364G96
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| Record Status |
Validated (UNII)
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| Record Version |
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54863-37-5
Created by
admin on Sat Dec 16 08:45:23 GMT 2023 , Edited by admin on Sat Dec 16 08:45:23 GMT 2023
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12714644
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2Z03364G96
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Dapansutrile
Created by
admin on Sat Dec 16 08:45:23 GMT 2023 , Edited by admin on Sat Dec 16 08:45:23 GMT 2023
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10228
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admin on Sat Dec 16 08:45:23 GMT 2023 , Edited by admin on Sat Dec 16 08:45:23 GMT 2023
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DTXSID601336541
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DE-129
Created by
admin on Sat Dec 16 08:45:23 GMT 2023 , Edited by admin on Sat Dec 16 08:45:23 GMT 2023
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C166608
Created by
admin on Sat Dec 16 08:45:23 GMT 2023 , Edited by admin on Sat Dec 16 08:45:23 GMT 2023
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300000034097
Created by
admin on Sat Dec 16 08:45:23 GMT 2023 , Edited by admin on Sat Dec 16 08:45:23 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> INHIBITOR |
OLT1177 reduces the release of mature IL-1β by preventing NLRP3 inflammasome oligomerization.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
