U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula 2C3H5O3.Ca
Molecular Weight 218.218
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CALCIUM LACTATE ANHYDROUS

SMILES

[Ca++].CC(O)C([O-])=O.CC(O)C([O-])=O

InChI

InChIKey=MKJXYGKVIBWPFZ-UHFFFAOYSA-L
InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula C3H5O3
Molecular Weight 89.07
Charge -1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260884.htm | http://www.webmd.com/drugs/2/drug-159847/calcium-phosphate-dibasic-oral/details

Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes.
2000 Dec
Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.
2000 Dec
Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.
2000 Nov
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
2000 Nov 10
Ca2+-induced contraction of cat esophageal circular smooth muscle cells.
2001 Apr
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity.
2001 Apr 27
Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.
2001 Apr 7
Endothelin-induced changes of secondary messengers in cultured corneal endothelial cells.
2001 Aug
Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity.
2001 Aug 28
Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.
2001 Dec 21
Complement activation in factor D-deficient mice.
2001 Dec 4
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
2001 Feb 16
Molecular and functional characterization of a family of rat brain T-type calcium channels.
2001 Feb 9
Extracellular calcium-sensing receptor is expressed in rat hepatocytes. coupling to intracellular calcium mobilization and stimulation of bile flow.
2001 Feb 9
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
2001 Jul
Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine.
2001 Jul
Analysis of the native quaternary structure of vanilloid receptor 1.
2001 Jul 27
Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B.
2001 Jun
Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components.
2001 Jun
Vasopressin-stimulated Ca2+ spiking in vascular smooth muscle cells involves phospholipase D.
2001 Jun
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
2001 Jun 8
Cloning and characterization of a novel human histamine receptor.
2001 Mar
Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.
2001 Mar 15
Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes.
2001 Mar 2
RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
2001 Mar 27
Activating mutations of the calcium-sensing receptor: management of hypocalcemia.
2001 Nov
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
2001 Nov 30
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
2001 Oct
Familial intrahepatic cholestasis 1: studies of localization and function.
2001 Oct
Microarray analysis of differential gene expression in lead-exposed astrocytes.
2001 Oct 1
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.
2001 Oct 12
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.
2001 Sep
Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism.
2001 Sep
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore.
2001 Sep 1
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
2001 Sep 7
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
2002
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002 Apr 19
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.
2002 Dec
CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.
2002 Feb
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
2002 Feb
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
2002 Feb 1
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Human kidney diamine oxidase: heterologous expression, purification, and characterization.
2002 Jun
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
2002 Mar
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
2002 Mar
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.
2002 Mar 15
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
2002 Sep 15
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.
2003 Jan
Patents

Sample Use Guides

oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:07:11 UTC 2023
Edited
by admin
on Sat Dec 16 10:07:11 UTC 2023
Record UNII
2URQ2N32W3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM LACTATE
FCC   HSDB   II   INCI   MI   USP   VANDF   WHO-DD  
EP   INCI  
Preferred Name English
CALCIUM LACTATE ANHYDROUS
Common Name English
INS NO.327
Code English
2-HYDROXYPROPANOIC ACID CALCIUM SALT
Common Name English
CALCIUM LACTATE [FCC]
Common Name English
CALCIUM LACTATE [II]
Common Name English
Calcium lactate [WHO-DD]
Common Name English
CALCIUM LACTATE [INCI]
Common Name English
CALCIUM (AS LACTATE) [VANDF]
Common Name English
CALCIUM LACTATE, ANHYDROUS
EP  
Common Name English
PROPANOIC ACID, 2-HYDROXY-, CALCIUM SALT (2:1)
Common Name English
E-327
Code English
CALPHOSAN
Brand Name English
(±)-LACTIC ACID, CALCIUM SALT (2:1)
Common Name English
CALCIUM LACTATE [MI]
Common Name English
CALCIUM LACTATE [VANDF]
Common Name English
CALCIUM LACTATE ANHYDROUS [USP MONOGRAPH]
Common Name English
CALCIUM (AS LACTATE)
VANDF  
Common Name English
CALCIUM LACTATE [HSDB]
Common Name English
CALCIUM LACTATE (1:2)
Systematic Name English
INS-327-
Code English
CALCIUM LACTATE [EP MONOGRAPH]
Common Name English
CALCIUM LACTATE, ANHYDROUS [EP IMPURITY]
Common Name English
INS-327
Code English
CALCIUM DILACTATE
Systematic Name English
CALCIUM LACTATE [USP-RS]
Common Name English
LACTIC ACID, CALCIUM SALT (2:1)
Common Name English
Classification Tree Code System Code
WHO-VATC QA12AA05
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
CFR 21 CFR 184.1207
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
CODEX ALIMENTARIUS (GSFA) INS-327
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
JECFA EVALUATION INS-327
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
WHO-ATC A12AA05
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
EPA PESTICIDE CODE 298
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
Code System Code Type Description
FDA UNII
2URQ2N32W3
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
DRUG CENTRAL
4383
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
CONCEPT Dietary Supplement
ChEMBL
CHEMBL2106111
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
PUBCHEM
13144
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
HSDB
976
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
SMS_ID
100000092155
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
ECHA (EC/EINECS)
212-406-7
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
DRUG BANK
DB13231
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
DAILYMED
2URQ2N32W3
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
MESH
C110051
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
MERCK INDEX
m2950
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
CALCIUM LACTATE
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
CAS
814-80-2
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
RXCUI
47622
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY RxNorm
EVMPD
SUB13184MIG
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
RS_ITEM_NUM
1086888
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
NCI_THESAURUS
C76830
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
EPA CompTox
DTXSID0020236
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
747
Created by admin on Sat Dec 16 10:07:12 UTC 2023 , Edited by admin on Sat Dec 16 10:07:12 UTC 2023
PRIMARY
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
SOLVATE->ANHYDROUS
Related Record Type Details
ACTIVE MOIETY