AZD6703 DIMESYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H27N5O2.2CH4O3S
Molecular Weight	609.715
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.CS(O)(=O)=O.CN1CCN(CC1)C2=CC=C3N=CN(C(=O)C3=C2)C4=CC(=CC=C4C)C(=O)NC5CC5

InChI

InChIKey=JSXSVADGVXBVRO-UHFFFAOYSA-N

InChI=1S/C24H27N5O2.2CH4O3S/c1-16-3-4-17(23(30)26-18-5-6-18)13-22(16)29-15-25-21-8-7-19(14-20(21)24(29)31)28-11-9-27(2)10-12-28;2*1-5(2,3)4/h3-4,7-8,13-15,18H,5-6,9-12H2,1-2H3,(H,26,30);2*1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C24H27N5O2
Molecular Weight	417.5035
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.	2012-06-15	22608965
Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease.	2007-11	17765316
The p38 MAP kinase pathway as a therapeutic target in inflammatory disease.	2004-08	15251131

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 20:17:20 GMT 2025` Edited by `admin` on `Wed Apr 02 20:17:20 GMT 2025`
Record UNII	2S97TJ8YLD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD6703 DIMESYLATE

Preferred Name

English

N-Cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4h)-yl]benzamide bismethanesulfonate salt

Systematic Name

English

Benzamide, N-cyclopropyl-4-methyl-3-[6-(4-methyl-1-piperazinyl)-4-oxo-3(4H)-quinazolinyl]-, dimethanesulfonate

Systematic Name

English

Benzamide, N-cyclopropyl-4-methyl-3-[6-(4-methyl-1-piperazinyl)-4-oxo-3(4H)-quinazolinyl]-, methanesulfonate (1:2)

Systematic Name

English

Code System Code Type Description

CAS

851846-76-9

Created by admin on Wed Apr 02 20:17:20 GMT 2025 , Edited by admin on Wed Apr 02 20:17:20 GMT 2025

PRIMARY

PUBCHEM

86610969

Created by admin on Wed Apr 02 20:17:20 GMT 2025 , Edited by admin on Wed Apr 02 20:17:20 GMT 2025

PRIMARY

FDA UNII

2S97TJ8YLD

Created by admin on Wed Apr 02 20:17:20 GMT 2025 , Edited by admin on Wed Apr 02 20:17:20 GMT 2025

PRIMARY

Related Record Type Details


					8QS8G2Y8E0

AZD-6703

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					8QS8G2Y8E0

AZD-6703

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
log D	CHEMICAL				pH CHEMICAL
SOLUBILITY	CHEMICAL		`059QF0KO0R` WATER		pH CHEMICAL