GUANACLINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H18N4
Molecular Weight	182.266
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of GUANACLINE

Structure Search

SMILES

CC1=CCN(CCNC(N)=N)CC1

InChI

InChIKey=WQVAYGCXSJMPRT-UHFFFAOYSA-N

InChI=1S/C9H18N4/c1-8-2-5-13(6-3-8)7-4-12-9(10)11/h2H,3-7H2,1H3,(H4,10,11,12)

HIDE SMILES / InChI

Molecular Formula	C9H18N4
Molecular Weight	182.266
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5420832

Guanacline was studied in the treatment of hypertension. However, information about the current use of this compound is not available.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Species and structural specificity of the lipopigment accumulation and neuronal destruction induced by N-(2-guanidinoethyl)-4-methyl-1,2,5,6-tetrahydropyridine (guanacline).	1986-09-24	3768685
Clinical experiences with Leron (guanacline) in the treatment of hypertension.	1970-05-09	5420832
Guanacline, a new hypotensive drug.	1969-01-25	5779041

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:33:59 GMT 2025` Edited by `admin` on `Mon Mar 31 17:33:59 GMT 2025`
Record UNII	2S93M1DW13
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GUANACLINE

Official Name

English

GUANACLINE [MI]

Preferred Name

English

guanacline [INN]

Common Name

English

(2-(3,6-DIHYDRO-4-METHYL-1(2H)-PYRIDYL)ETHYL)GUANIDINE

Systematic Name

English

GUANIDINE, (2-(3,6-DIHYDRO-4-METHYL-1(2H)-PYRIDINYL)ETHYL)-

Systematic Name

English

Guanacline [WHO-DD]

Common Name

English

Code System Code Type Description

MERCK INDEX

m221

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

PRIMARY

Merck Index

EVMPD

SUB07979MIG

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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MESH

C004943

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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NCI_THESAURUS

C166589

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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PUBCHEM

15102

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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FDA UNII

2S93M1DW13

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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SMS_ID

100000084451

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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CAS

1463-28-1

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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ChEMBL

CHEMBL1160385

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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INN

2150

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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EPA CompTox

DTXSID90163350

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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DRUG CENTRAL

3454

Created by admin on Mon Mar 31 17:33:59 GMT 2025 , Edited by admin on Mon Mar 31 17:33:59 GMT 2025

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