Nelmastobart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:33:23 GMT 2025` Edited by `admin` on `Wed Apr 02 12:33:23 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	2S69ME4B3R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HSTC-810

Preferred Name

English

Nelmastobart

Official Name

English

HSTC810

Code

English

Immunoglobulin G4-kappa, anti-[Homo sapiens BTN1A1 (butyrophilin subfamily 1 member A1)], humanized monoclonal antibody

Common Name

English

NELMASTOBART [USAN]

Common Name

English

Nelmastobart [WHO-DD]

Common Name

English

nelmastobart [INN]

Common Name

English

Gamma4 heavy chain humanized(1-452) [VH (Homo sapiens IGHV1-46*01 (84.7%) -(IGHD) -IGHJ3*01 (92.9%) M123>T (120), CDR-IMGT [8.8.18] (26-33.51-58.97-114)) (1-125)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (126-223), hinge 1-12 S10>P(233) (22

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190185

Created by admin on Wed Apr 02 12:33:23 GMT 2025 , Edited by admin on Wed Apr 02 12:33:23 GMT 2025

PRIMARY

INN

12640

Created by admin on Wed Apr 02 12:33:23 GMT 2025 , Edited by admin on Wed Apr 02 12:33:23 GMT 2025

PRIMARY

USAN

MN-279

Created by admin on Wed Apr 02 12:33:23 GMT 2025 , Edited by admin on Wed Apr 02 12:33:23 GMT 2025

PRIMARY

SMS_ID

300000051905

Created by admin on Wed Apr 02 12:33:23 GMT 2025 , Edited by admin on Wed Apr 02 12:33:23 GMT 2025

PRIMARY

FDA UNII

2S69ME4B3R

Created by admin on Wed Apr 02 12:33:23 GMT 2025 , Edited by admin on Wed Apr 02 12:33:23 GMT 2025

PRIMARY

CAS

2669823-48-5

Created by admin on Wed Apr 02 12:33:23 GMT 2025 , Edited by admin on Wed Apr 02 12:33:23 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_139	4_214
2_152	2_208
2_266	2_326
1_139	3_214
2_372	2_430
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_152	1_208
1_231	2_231
1_234	2_234
1_266	1_326
1_372	1_430

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					RL4EZ6U8UV

BUTYROPHILIN SUBFAMILY 1 MEMBER A1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					2S69ME4B3R

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_452] [2_452]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL