HOQUIZIL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H26N4O5
Molecular Weight	390.4335
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HOQUIZIL

Structure Search

SMILES

COC1=CC2=C(C=C1OC)C(=NC=N2)N3CCN(CC3)C(=O)OCC(C)(C)O

InChI

InChIKey=YRTMGQYDLITGNA-UHFFFAOYSA-N

InChI=1S/C19H26N4O5/c1-19(2,25)11-28-18(24)23-7-5-22(6-8-23)17-13-9-15(26-3)16(27-4)10-14(13)20-12-21-17/h9-10,12,25H,5-8,11H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C19H26N4O5
Molecular Weight	390.4335
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4912116 | https://www.ncbi.nlm.nih.gov/pubmed/6276530

Hoquizil, a phosphodiesterase inhibitor, was used as a bronchodilator agent. Information about the current use of this drug is not available.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
phosphoric diester hydrolase activity 4 Target ID: GO:0008081 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276530	Inhibitor 8297

PubMed

PubMed

Title	Date	PubMed
Heterogeneity of biochemical actions among vasodilators.	1982 Jan	6276530

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:16:48 GMT 2023` Edited by `admin` on `Sat Dec 16 16:16:48 GMT 2023`
Record UNII	2MP2H1GQ03
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HOQUIZIL

Official Name

English

hoquizil [INN]

Common Name

English

2-HYDROXY-2-METHYLPROPYL 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-1-PIPERAZINECARBOXYLATE

Systematic Name

English

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-HYDROXY-2-METHYLPROPYL ESTER

Common Name

English

Code System Code Type Description

CAS

21560-59-8

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

PRIMARY

EVMPD

SUB08056MIG

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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INN

2634

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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FDA UNII

2MP2H1GQ03

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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EPA CompTox

DTXSID30175896

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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SMS_ID

100000084191

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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NCI_THESAURUS

C166582

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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ChEMBL

CHEMBL2110858

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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PUBCHEM

30690

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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Related Record Type Details


					9I598ZX18I

HOQUIZIL HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					2MP2H1GQ03

HOQUIZIL

ACTIVE MOIETY