HOQUIZIL

COC1=CC2=C(C=C1OC)C(=NC=N2)N3CCN(CC3)C(=O)OCC(C)(C)O

InChIKey=YRTMGQYDLITGNA-UHFFFAOYSA-N

InChI=1S/C19H26N4O5/c1-19(2,25)11-28-18(24)23-7-5-22(6-8-23)17-13-9-15(26-3)16(27-4)10-14(13)20-12-21-17/h9-10,12,25H,5-8,11H2,1-4H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Hoquizil, a phosphodiesterase inhibitor, was used as a bronchodilator agent. Information about the current use of this drug is not available.

Targets

Primary Target	Pharmacology	Condition	Potency
phosphoric diester hydrolase activity 4 Target ID: GO:0008081 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276530	Inhibitor 8297

PubMed

Title	Date	PubMed
Hoquizil--a new oral bronchodilator. A double-blind, randomized, coded clinical study using body plethysmography.	1969	4912116
Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators.	1971	4946165
Heterogeneity of biochemical actions among vasodilators.	1982 Jan	6276530

In Vivo Use Guide

Unknown

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:16:48 GMT 2023` Edited by `admin` on `Sat Dec 16 16:16:48 GMT 2023`
Record UNII	2MP2H1GQ03
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

HOQUIZIL

Official Name

English

hoquizil [INN]

Common Name

English

2-HYDROXY-2-METHYLPROPYL 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-1-PIPERAZINECARBOXYLATE

Systematic Name

English

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-HYDROXY-2-METHYLPROPYL ESTER

Common Name

English

Code System Code Type Description

CAS

21560-59-8