HOQUIZIL HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H26N4O5.ClH
Molecular Weight	426.894
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC2=C(C=C1OC)C(=NC=N2)N3CCN(CC3)C(=O)OCC(C)(C)O

InChI

InChIKey=UGBDUZVYTXIXHU-UHFFFAOYSA-N

InChI=1S/C19H26N4O5.ClH/c1-19(2,25)11-28-18(24)23-7-5-22(6-8-23)17-13-9-15(26-3)16(27-4)10-14(13)20-12-21-17;/h9-10,12,25H,5-8,11H2,1-4H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H26N4O5
Molecular Weight	390.4335
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4912116 | https://www.ncbi.nlm.nih.gov/pubmed/6276530

Hoquizil, a phosphodiesterase inhibitor, was used as a bronchodilator agent. Information about the current use of this drug is not available.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
phosphoric diester hydrolase activity 4 Target ID: GO:0008081 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276530	Inhibitor 8297

PubMed

Title	Date	PubMed
Hoquizil--a new oral bronchodilator. A double-blind, randomized, coded clinical study using body plethysmography.	1969	4912116
Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators.	1971	4946165
Heterogeneity of biochemical actions among vasodilators.	1982 Jan	6276530

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:11:21 GMT 2023` Edited by `admin` on `Fri Dec 15 15:11:21 GMT 2023`
Record UNII	9I598ZX18I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HOQUIZIL HYDROCHLORIDE

Official Name

English

HOQUIZIL HYDROCHLORIDE [USAN]

Common Name

English

CP-14,185-1

Code

English

HOQUIZIL HCL

Common Name

English

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-HYDROXY-2-METHYLPROPYL ESTER, MONOHYDROCHLORIDE

Common Name

English

CP-14185-1

Code

English

2-Hydroxy-2-methylpropyl 4-(6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylate monohydrochloride

Systematic Name

English

Code System Code Type Description

ChEMBL

CHEMBL2110858