CRISNATOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H23NO2
Molecular Weight	345.4342
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CO)(CO)NCC1=CC2=C(C=CC3=CC=CC=C23)C4=C1C=CC=C4

InChI

InChIKey=SBRXTSOCZITGQG-UHFFFAOYSA-N

InChI=1S/C23H23NO2/c1-23(14-25,15-26)24-13-17-12-22-18-7-3-2-6-16(18)10-11-21(22)20-9-5-4-8-19(17)20/h2-12,24-26H,13-15H2,1H3

HIDE SMILES / InChI

Molecular Formula	C23H23NO2
Molecular Weight	345.4342
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3396016 | https://www.ncbi.nlm.nih.gov/pubmed/2819712 | https://www.ncbi.nlm.nih.gov/pubmed/2391683 | https://www.ncbi.nlm.nih.gov/pubmed/9547677

Crisnatol is a derivative of arylmethylaminopropanediol with significant antineoplastic activity in a variety of murine and human tumor models. Crisnatol functions as a DNA intercalator, with the presence of additional basic amine groups in the sidechain enhancing binding to DNA due to electrostatic interactions. Crisnatol did not show antitumor efficacy in patients with ovarian carcinoma. In another clinical study, 2 of 26 patients with glioma showed complete long-lasting responses to the drug. The dose-limiting side effect was neurotoxicity.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:25:13 UTC 2023` Edited by `admin` on `Sat Dec 16 17:25:13 UTC 2023`
Record UNII	2J71UR51UE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CRISNATOL

Official Name

English

2-((6-CHRYSENYLMETHYL)AMINO)-2-METHYL-1,3-PROPANEDIOL

Systematic Name

English

crisnatol [INN]

Common Name

English

1,3-PROPANEDIOL, 2-((6-CHRYSENYLMETHYL)AMINO)-2-METHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C582