CRISNATOL MESYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H23NO2.CH4O3S
Molecular Weight	441.54
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.CC(CO)(CO)NCC1=CC2=C3C=CC=CC3=CC=C2C4=CC=CC=C14

InChI

InChIKey=NJWBUDCAWGTQAS-UHFFFAOYSA-N

InChI=1S/C23H23NO2.CH4O3S/c1-23(14-25,15-26)24-13-17-12-22-18-7-3-2-6-16(18)10-11-21(22)20-9-5-4-8-19(17)20;1-5(2,3)4/h2-12,24-26H,13-15H2,1H3;1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C23H23NO2
Molecular Weight	345.4342
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3396016 | https://www.ncbi.nlm.nih.gov/pubmed/2819712 | https://www.ncbi.nlm.nih.gov/pubmed/2391683 | https://www.ncbi.nlm.nih.gov/pubmed/9547677

Crisnatol is a derivative of arylmethylaminopropanediol with significant antineoplastic activity in a variety of murine and human tumor models. Crisnatol functions as a DNA intercalator, with the presence of additional basic amine groups in the sidechain enhancing binding to DNA due to electrostatic interactions. Crisnatol did not show antitumor efficacy in patients with ovarian carcinoma. In another clinical study, 2 of 26 patients with glioma showed complete long-lasting responses to the drug. The dose-limiting side effect was neurotoxicity.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:02:56 UTC 2023` Edited by `admin` on `Fri Dec 15 15:02:56 UTC 2023`
Record UNII	R6D31YA2WK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CRISNATOL MESYLATE

Official Name

English

CRISNATOL MESYLATE [USAN]

Common Name

English

BW A770U MESYLATE

Code

English

BW A770U MESILATE

Common Name

English

1,3-PROPANEDIOL, 2-((6-CHRYSENYLMETHYL)AMINO)-2-METHYL-, METHANESULPHONATE (SALT)

Common Name

English

2-((6-CHRYSENYLMETHYL)AMINO)-2-METHYL-1,3-PROPANEDIOL METHANESULPHONATE (SALT)

Common Name

English

BW-A-770U MESYLATE

Code

English

2-[(6-Chrysenylmethyl)amino]-2-methyl-1,3-propanediol methanesulfonate (salt)

Common Name

English

CRISNATOL MESILATE

Common Name

English

1,3-PROPANEDIOL, 2-((6-CHRYSENYLMETHYL)AMINO)-2-METHYL-, METHANESULFONATE (SALT)

Common Name

English

CRISNATOL MESILATE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C582