SEMORPHONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H23NO5
Molecular Weight	345.3896
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(CCOC)[C@H](C4)[C@]5(O)CCC2=O

InChI

InChIKey=PBGIBLLOMGURPS-GRGSLBFTSA-N

InChI=1S/C19H23NO5/c1-24-9-8-20-7-6-18-15-11-2-3-12(21)16(15)25-17(18)13(22)4-5-19(18,23)14(20)10-11/h2-3,14,17,21,23H,4-10H2,1H3/t14-,17+,18+,19-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C19H23NO5
Molecular Weight	345.3896
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7957512

Semorphone (previously known as Mr 2264), a partial opiate receptor agonist that was in two times more potent than morphine. Semorphone has a ceiling effect on both analgesia and respiratory depression; it means that these effects stop becoming any stronger after a certain maximum dose.

Approval Year

PubMed

Title	Date	PubMed
Respiratory effects and tolerability of Mr 2264 Cl. A new opiate partial agonist in comparison with morphine and placebo.	1994	7957512

Sample Use Guides

In Vivo Use Guide

M(r) 2264 Cl (SEMORPHONE) 2 x 5 mg i.v.,

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:56:53 GMT 2023` Edited by `admin` on `Fri Dec 15 15:56:53 GMT 2023`
Record UNII	2HD55617I2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SEMORPHONE

Official Name

English

N-(2-Methoxyethyl)noroxymorphone

Common Name

English

semorphone [INN]

Common Name

English

MR2264

Code

English

MR-2264

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C67413