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Details

Stereochemistry ACHIRAL
Molecular Formula Co.2NO3.6H2O
Molecular Weight 291.0347
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS NITRATE HEXAHYDRATE

SMILES

O.O.O.O.O.O.[Co++].[O-][N+]([O-])=O.[O-][N+]([O-])=O

InChI

InChIKey=QGUAJWGNOXCYJF-UHFFFAOYSA-N
InChI=1S/Co.2NO3.6H2O/c;2*2-1(3)4;;;;;;/h;;;6*1H2/q+2;2*-1;;;;;;

HIDE SMILES / InChI
Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Erythropoietic effect of cobalt in patients with or without anemia.
1949 May 12
Improved methods for cobalt filling and silver intensification of insect motor neurons.
1982 Jul
Acute oral toxicity of inorganic cobalt compounds in rats.
1982 Jun
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline).
1999
Determination of trace metal ions in common salt by stripping voltammetry.
1999 Nov-Dec
Cobalt and antimony: genotoxicity and carcinogenicity.
2003 Dec 10
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
2009 Apr
In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles.
2015 Dec
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.
2016 Aug 15
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:32:06 GMT 2023
Edited
by admin
on Fri Dec 15 17:32:06 GMT 2023
Record UNII
2H2166872F
Record Status Validated (UNII)
Record Version
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Name Type Language
COBALTOUS NITRATE HEXAHYDRATE
MI  
Common Name English
COBALT(2+) NITRATE HEXAHYDRATE
Systematic Name English
COBALT(II) NITRATE HEXAHYDRATE
Systematic Name English
COBALTOUS NITRATE HEXAHYDRATE [MI]
Common Name English
NITRIC ACID, COBALT(2+) SALT, HEXAHYDRATE
Common Name English
COBALTUM NITRICUM [HPUS]
Common Name English
COBALTUM NITRICUM
HPUS  
Common Name English
COBALT NITRATE HEXAHYDRATE
Systematic Name English
COBALT DINITRATE HEXAHYDRATE
Systematic Name English
Code System Code Type Description
DAILYMED
2H2166872F
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID3073135
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY
MERCK INDEX
m3698
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY Merck Index
MESH
C025913
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY
CAS
10026-22-9
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY
CHEBI
86214
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY
FDA UNII
2H2166872F
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY
RXCUI
1423922
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY RxNorm
PUBCHEM
24821
Created by admin on Fri Dec 15 17:32:06 GMT 2023 , Edited by admin on Fri Dec 15 17:32:06 GMT 2023
PRIMARY
Related Record Type Details
Structure of COBALTOUS NITRATE
ANHYDROUS->SOLVATE
Structure of COBALTOUS CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of COBALTOUS CATION
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