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Details

Stereochemistry ACHIRAL
Molecular Formula Co.2NO3
Molecular Weight 182.943
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS NITRATE

SMILES

[Co++].[O-][N+]([O-])=O.[O-][N+]([O-])=O

InChI

InChIKey=UFMZWBIQTDUYBN-UHFFFAOYSA-N
InChI=1S/Co.2NO3/c;2*2-1(3)4/q+2;2*-1

HIDE SMILES / InChI

Molecular Formula Co
Molecular Weight 58.933195
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Cobalt is a transition metal, naturally ocurring in the minerals cobaltite, smaltite, and erythrite, and is often associated with nickel, silver, lead, copper, and iron ores, from which it is most frequently obtained as a by-product. Depending on the considered species, cobalt has multiple industrial applications including the production of alloys and hard metal, diamond polishing, drying agents, pigments and catalysts. Cobalt is an essential component of Vitamin B12 (hydroxycolalamin). Cobalt functions as a co-factor in enzyme catalysed reactions and is involved in the production of erythropoietin, a hormone that stimulates the formation of erythrocytes. Cobalt salts were used to treat anemia and stimulate erythropoiesis, but was withdrawn from market since Co(II) cations are genotoxic in vitro and in vivo, and carcinogenic in rodents. Hovewer, Co salts are reported to be used by athletes as a doping

Originator

Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
1.0 µM [Ki]
Conditions
PubMed

PubMed

TitleDatePubMed
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.
2016-08-15
In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles.
2015-12
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity.
2015-05
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.
2013-09
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
2009-04
Synthesis and antifungal potential of Co(II) complexes of 1-(2'-hydroxyphenyl) ethylideneanilines.
2006-02
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005-08
Cobalt and antimony: genotoxicity and carcinogenicity.
2003-12-10
Determination of trace metal ions in common salt by stripping voltammetry.
1999-12-10
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline).
1999
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
1990-12-01
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.
1990-08
Improved methods for cobalt filling and silver intensification of insect motor neurons.
1982-07
Acute oral toxicity of inorganic cobalt compounds in rats.
1982-06
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.
1975-05-02
Erythropoietic effect of cobalt in patients with or without anemia.
1949-05-12
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:37:44 GMT 2025
Edited
by admin
on Mon Mar 31 18:37:44 GMT 2025
Record UNII
65W79BFD5V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COBALTOUS NITRATE
HSDB   MI  
Common Name English
COBALT NITRATE
WHO-DD  
Preferred Name English
COBALTOUS NITRATE [MI]
Common Name English
COBALT NITRATE (CO(NO3)2)
Common Name English
COBALTOUS NITRATE [HSDB]
Common Name English
COBALT DINITRATE
Systematic Name English
COBALT(2+) NITRATE
Systematic Name English
Cobalt nitrate [WHO-DD]
Common Name English
NITRIC ACID, COBALT(2+) SALT
Common Name English
COBALT(II) NITRATE
Systematic Name English
COBALT (II) NITRATE
Systematic Name English
Code System Code Type Description
SMS_ID
100000079784
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
HSDB
238
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
MERCK INDEX
m3698
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY Merck Index
PUBCHEM
25000
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
CAS
10141-05-6
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
ECHA (EC/EINECS)
233-402-1
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
CHEBI
86209
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
WIKIPEDIA
COBALT(II) NITRATE
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
DAILYMED
65W79BFD5V
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
EPA CompTox
DTXSID9064970
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
EVMPD
SUB13411MIG
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
FDA UNII
65W79BFD5V
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
MESH
C025913
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY
RXCUI
1423923
Created by admin on Mon Mar 31 18:37:44 GMT 2025 , Edited by admin on Mon Mar 31 18:37:44 GMT 2025
PRIMARY RxNorm
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE