Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C44H60FN3O10 |
| Molecular Weight | 809.9597 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1)[C@@H]2[C@@H](CC[C@H](O)C3=CC=C(F)C=C3)C(=O)N2C4=CC=C(CNC(=O)CCCCCCCCCCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C=C4
InChI
InChIKey=JGNXLPQJHVVQHB-GXPLPOFXSA-N
InChI=1S/C44H60FN3O10/c1-58-34-22-16-31(17-23-34)41-35(24-25-36(50)30-14-18-32(45)19-15-30)44(57)48(41)33-20-12-29(13-21-33)26-46-39(53)10-8-6-4-2-3-5-7-9-11-40(54)47-27-37(51)42(55)43(56)38(52)28-49/h12-23,35-38,41-43,49-52,55-56H,2-11,24-28H2,1H3,(H,46,53)(H,47,54)/t35-,36+,37+,38-,41-,42-,43-/m1/s1
| Molecular Formula | C44H60FN3O10 |
| Molecular Weight | 809.9597 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Canosimibe is diphenyl azetidinone patented by German pharmaceutical company Aventis Pharma Deutschland GmbH as hypolipidemic agent. Canosimibe acts as pre-systemic inhibition of intestinal cholesterol absorption. Unfortunately, during phase II clinical trials Canosimibe failed to demonstrate efficacy in in patients with primary severe hypercholesterolemia.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:44:46 GMT 2025
by
admin
on
Mon Mar 31 18:44:46 GMT 2025
|
| Record UNII |
2GG0K1I5CI
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C29703
Created by
admin on Mon Mar 31 18:44:46 GMT 2025 , Edited by admin on Mon Mar 31 18:44:46 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
2GG0K1I5CI
Created by
admin on Mon Mar 31 18:44:46 GMT 2025 , Edited by admin on Mon Mar 31 18:44:46 GMT 2025
|
PRIMARY | |||
|
9077
Created by
admin on Mon Mar 31 18:44:46 GMT 2025 , Edited by admin on Mon Mar 31 18:44:46 GMT 2025
|
PRIMARY | |||
|
9875746
Created by
admin on Mon Mar 31 18:44:46 GMT 2025 , Edited by admin on Mon Mar 31 18:44:46 GMT 2025
|
PRIMARY | |||
|
768394-99-6
Created by
admin on Mon Mar 31 18:44:46 GMT 2025 , Edited by admin on Mon Mar 31 18:44:46 GMT 2025
|
PRIMARY | |||
|
C91027
Created by
admin on Mon Mar 31 18:44:46 GMT 2025 , Edited by admin on Mon Mar 31 18:44:46 GMT 2025
|
PRIMARY | |||
|
100000175416
Created by
admin on Mon Mar 31 18:44:46 GMT 2025 , Edited by admin on Mon Mar 31 18:44:46 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
SALT/SOLVATE -> PARENT |
|
||
|
TARGET -> INHIBITOR |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|
