BEMARINONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12N2O3
Molecular Weight	220.2246
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C2NC(=O)N=C(C)C2=C1OC

InChI

InChIKey=WVNXGAOAWSQPAL-UHFFFAOYSA-N

InChI=1S/C11H12N2O3/c1-6-9-7(13-11(14)12-6)4-5-8(15-2)10(9)16-3/h4-5H,1-3H3,(H,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C11H12N2O3
Molecular Weight	220.2246
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://doi.org/10.1002/ddr.430120307| | https://www.ncbi.nlm.nih.gov/pubmed/3039135

Bemarinone (ORF 16600) is a positive inotropic and vasodilator agent with potential clinical utility in the management of congestive heart failure. The compound selectively and competitively inhibited cyclic AMP phosphodiesterase fraction III. However, further studies were discontinued

Originator

Approval Year

PubMed

Title	Date	PubMed
Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones.	1987 Aug	3039135
Cardiotonic agents. Synthesis and inotropic activity of a series of isoquinolin-3-ol derivatives.	1988 Jul	3385731

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:08:40 GMT 2023` Edited by `admin` on `Fri Dec 15 16:08:40 GMT 2023`
Record UNII	29J330V3XV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BEMARINONE

Official Name

English

2(1H)-QUINAZOLINONE, 5,6-DIMETHOXY-4-METHYL-

Systematic Name

English

bemarinone [INN]

Common Name

English

5,6-DIMETHYL-4-METHYL-2(1H)-QUINAZOLINONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78322