Approval Year
| Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Sat Dec 16 01:10:18 UTC 2023
by
admin
on
Sat Dec 16 01:10:18 UTC 2023
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| Source Materials Class | ORGANISM |
| Source Materials Type | VIRUS |
| Organism Family | Herpesviridae |
| Organism Genus | Simplexvirus |
| Organism Species | human herpesvirus 1 |
| Author | NONE |
| Part | WHOLE |
| Record UNII |
22G38P19RL
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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1316105
Created by
admin on Sat Dec 16 01:10:18 UTC 2023 , Edited by admin on Sat Dec 16 01:10:18 UTC 2023
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PRIMARY | RxNorm | ||
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SUB181348
Created by
admin on Sat Dec 16 01:10:18 UTC 2023 , Edited by admin on Sat Dec 16 01:10:18 UTC 2023
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22G38P19RL
Created by
admin on Sat Dec 16 01:10:18 UTC 2023 , Edited by admin on Sat Dec 16 01:10:18 UTC 2023
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22G38P19RL
Created by
admin on Sat Dec 16 01:10:18 UTC 2023 , Edited by admin on Sat Dec 16 01:10:18 UTC 2023
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C14311
Created by
admin on Sat Dec 16 01:10:18 UTC 2023 , Edited by admin on Sat Dec 16 01:10:18 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
IC50
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INFRASPECIFIC -> PARENT ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
The 9-(3,4-dihydroxybut-1-yl)guanine (bucyclovir, 23) with a hydroxyl directly attached to the butyl side chain is very potent against HSV-1 and HSV-2 (IC50=0.4 μM against HSV-1 and 0.9 μM against HSV-2). The stereochemistry of the 3-position of bucyclovir is crucial in determining the antiherpetic activities. While the R configuration is very potent, the S-isomer (24) is essentially inactive against HSV-1 and HSV-2
IC50
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INHIBITOR->TARGET ORGANISM |
The in vitro activities of penciclovir against HSV-1, HSV-2 and VZV are similar to those of aciclovir, with median IC50 values of 0.4, 1.5 and 4.0 µg/mL, respectively, in MRC-5 cells.
IC50
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INHIBITOR->TARGET ORGANISM |
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ACTIVE MOIETY |
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