HUMAN HERPESVIRUS 1

Approval Year

Substance Class	Structurally Diverse
Source Materials Class	ORGANISM
Source Materials Type	VIRUS
Organism Family	Herpesviridae
Organism Genus	Simplexvirus
Organism Species	human herpesvirus 1
Author	NONE
Part	WHOLE
Record UNII	22G38P19RL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HUMAN HERPESVIRUS 1

Common Name

English

Human alphaherpesvirus 1

Common Name

English

HERPES SIMPLEX VIRUS-1

Common Name

English

SIMPLEXVIRUS HUMAN HERPESVIRUS 1 WHOLE

Common Name

English

HSV-1

Common Name

English

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Code System

Code

Type

Description

RXCUI

1316105

PRIMARY

RxNorm

EVMPD

SUB181348

PRIMARY

FDA UNII

22G38P19RL

PRIMARY

DAILYMED

22G38P19RL

PRIMARY

NCI_THESAURUS

C14311

PRIMARY

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Type

Details


					07HQ1TJ4JE

PRITELIVIR

INHIBITOR->TARGET ORGANISM

Amount:


					X4HES1O11F

ACYCLOVIR

INHIBITOR->TARGET ORGANISM

Qualification:

IC50

Amount:

[0.2 to 13.5] microgram/mL (average)


					6C8AKH4VPP

Human herpesvirus 1 strain F

INFRASPECIFIC -> PARENT ORGANISM

Amount:


					W656S9I00W

DENOTIVIR

INHIBITOR->TARGET ORGANISM

Amount:


					4G4Z4676IS

BUCICLOVIR

INHIBITOR->TARGET ORGANISM

Comments:

The 9-(3,4-dihydroxybut-1-yl)guanine (bucyclovir, 23) with a hydroxyl directly attached to the butyl side chain is very potent against HSV-1 and HSV-2 (IC50=0.4 μM against HSV-1 and 0.9 μM against HSV-2). The stereochemistry of the 3-position of bucyclovir is crucial in determining the antiherpetic activities. While the R configuration is very potent, the S-isomer (24) is essentially inactive against HSV-1 and HSV-2

Qualification:

IC50

Amount:

0.4 MICROMOLAR (average)

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					22G38P19RL

HUMAN HERPESVIRUS 1

ACTIVE MOIETY

Amount:

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