Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C28H45NO5S |
| Molecular Weight | 507.726 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]3C)OC(=O)CS[C@@H]4CC[C@@H](N)C[C@H]4O
InChI
InChIKey=KPVIXBKIJXZQJX-CSOZIWFHSA-N
InChI=1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16?,17-,18+,20+,21+,22+,24-,25-,26+,27-,28-/m0/s1
| Molecular Formula | C28H45NO5S |
| Molecular Weight | 507.726 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
LEFAMULIN is a pleuromutilin antibiotic under development for the treatment of community-acquired bacterial pneumonia, as well as acute bacterial skin and skin structure infections. It inhibits bacterial protein synthesis by binding to the peptidyl transferase center of the 50S ribosome, resulting in the cessation of bacterial growth.
Originator
Approval Year
Sample Use Guides
Lefamulin was evaluated against various Streptococcus pneumoniae serotypes that were collected from adults with lower respiratory tract infections. Lefamulin exhibited MIC50 and MIC90 values of 0.12 and 0.25 μg/ml, respectively, against the entire collection (n = 822). Similar results were obtained for lefamulin against each of the most common serotypes as well as against multidrug-resistant isolates and strains that are nonsusceptible to ceftriaxone or erythromycin.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Oct 21 19:48:30 UTC 2019
by
admin
on
Mon Oct 21 19:48:30 UTC 2019
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| Record UNII |
21904A5386
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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CHEMBL3291398
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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PRIMARY | |||
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9849
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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25185057
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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1061337-51-6
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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PRIMARY |
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TARGET ORGANISM->INHIBITOR | |||
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
