ETIBENDAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H16FN3O4
Molecular Weight	357.3357
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)NC1=NC2=C(N1)C=C(C=C2)C3(OCCO3)C4=CC=C(F)C=C4

InChI

InChIKey=PEVOWKBJMJVUSV-UHFFFAOYSA-N

InChI=1S/C18H16FN3O4/c1-24-17(23)22-16-20-14-7-4-12(10-15(14)21-16)18(25-8-9-26-18)11-2-5-13(19)6-3-11/h2-7,10H,8-9H2,1H3,(H2,20,21,22,23)

HIDE SMILES / InChI

Molecular Formula	C18H16FN3O4
Molecular Weight	357.3357
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7207954 | https://link.springer.com/chapter/10.1007%2F978-1-4757-2085-3_5

Etibendazole (R34803 or methyl [5-(2-(4-fluorophenyl)-1,3-dioxolan-2-yl)-1H-benzimidazole-2-yl] carbamate), a benzimidazole derivative, is a microtubule inhibitor. Etibendazole exerts antihelmintic activity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
microtubule 3 Target ID: microtubule Sources: https://www.ncbi.nlm.nih.gov/pubmed/7207954	Inhibitor 8504

PubMed

Title	Date	PubMed
The pharmacokinetics of mebendazole and flubendazole in animals and man.	1982-04	7103610
Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro.	1981	7207954

Patents

Sample Use Guides

In Vitro Use Guide

Etibendazole at 1 microgram/ml inhibited invasion of mouse fibrosarcoma cells

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:28:05 GMT 2025` Edited by `admin` on `Mon Mar 31 18:28:05 GMT 2025`
Record UNII	1XU086MM3H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ETIBENDAZOLE

Official Name

English

R-34803

Preferred Name

English

CARBAMIC ACID, (5-(2-(4-FLUOROPHENYL)-1,3-DIOXOLAN-2-YL)-1H-BENZIMIDAZOL-2-YL)-, METHYL ESTER

Common Name

English

R-34,803

Code

English

NSC-313432

Code

English

etibendazole [INN]

Common Name

English

METHYL 5-(2-(P-FLUOROPHENYL)-1,3-DIOXOLAN-2-YL)-2-BENZIMIDAZOLECARBAMATE

Common Name

English

ETIBENDAZOLE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250