ETIBENDAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H16FN3O4
Molecular Weight	357.3357
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)NC1=NC2=CC=C(C=C2N1)C3(OCCO3)C4=CC=C(F)C=C4

InChI

InChIKey=PEVOWKBJMJVUSV-UHFFFAOYSA-N

InChI=1S/C18H16FN3O4/c1-24-17(23)22-16-20-14-7-4-12(10-15(14)21-16)18(25-8-9-26-18)11-2-5-13(19)6-3-11/h2-7,10H,8-9H2,1H3,(H2,20,21,22,23)

HIDE SMILES / InChI

Molecular Formula	C18H16FN3O4
Molecular Weight	357.3357
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7207954 | https://link.springer.com/chapter/10.1007%2F978-1-4757-2085-3_5

Etibendazole (R34803 or methyl [5-(2-(4-fluorophenyl)-1,3-dioxolan-2-yl)-1H-benzimidazole-2-yl] carbamate), a benzimidazole derivative, is a microtubule inhibitor. Etibendazole exerts antihelmintic activity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
microtubule 2 Target ID: microtubule Sources: https://www.ncbi.nlm.nih.gov/pubmed/7207954	Inhibitor 8297

PubMed

Title	Date	PubMed
Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro.	1981	7207954
The pharmacokinetics of mebendazole and flubendazole in animals and man.	1982 Apr	7103610

Patents

Sample Use Guides

In Vitro Use Guide

Etibendazole at 1 microgram/ml inhibited invasion of mouse fibrosarcoma cells

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:35 GMT 2023` Edited by `admin` on `Fri Dec 15 16:26:35 GMT 2023`
Record UNII	1XU086MM3H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETIBENDAZOLE

Official Name

English

CARBAMIC ACID, (5-(2-(4-FLUOROPHENYL)-1,3-DIOXOLAN-2-YL)-1H-BENZIMIDAZOL-2-YL)-, METHYL ESTER

Common Name

English

R-34,803

Code

English

NSC-313432

Code

English

R-34803

Code

English

etibendazole [INN]

Common Name

English

METHYL 5-(2-(P-FLUOROPHENYL)-1,3-DIOXOLAN-2-YL)-2-BENZIMIDAZOLECARBAMATE

Common Name

English

ETIBENDAZOLE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250