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Description
Curator's Comment: Description was created based on several sources, including http://www.adm.com/en-US/worldwide/australia/Documents/Potassium%20Citrate%20AU.pdf | https://noshly.com/additive/e332/acidity-regulator-plus/332/#.WUp-1uvyjIU

Potassium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones. WhenPotassium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. Potassium citrate is used as a food additive (E 332) to regulate acidity.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

4.94121615E11
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

4.94121615E11
Doses

Doses

DosePopulationAdverse events​
540 mg 1 times / day multiple, oral
Recommended
Dose: 540 mg, 1 times / day
Route: oral
Route: multiple
Dose: 540 mg, 1 times / day
Co-administed with::
Thiamin oral 1.1 mg
Arginine oral 1240 mg
caffeine oral 52 mg
Sources: Page: p.2326
healthy, 24-59
n = 16
Health Status: healthy
Age Group: 24-59
Sex: M+F
Population Size: 16
Sources: Page: p.2326
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.
1993
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.
2013 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Objective: To restore normal urinary citrate (greater than 320 mg/day and as close to the normal mean of 640 mg/day as possible), and to increase urinary pH to a level of 6.0 to 7.0. • Severe hypocitraturia (urinary citrate < 150 mg/day): therapy should be initiated at 60 mEq per day; a dose of 30 mEq two times per day or 20 mEq three times per day with meals or within 30 minutes after meals or bedtime snack • Mild to moderate hypocitraturia (urinary citrate >150 mg/day): therapy should be initiated at 30 mEq per day; a dose of 15 mEq two times per day or 10 mEq three times per day with meals or within 30 minutes after meals or bedtime snack
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Mixture
Created
by admin
on Fri Dec 15 16:29:14 UTC 2023
Edited
by admin
on Fri Dec 15 16:29:14 UTC 2023
Record UNII
1Q73Q2JULR
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
SODIUM CITRATE
II   INCI   ORANGE BOOK   USP   VANDF   WHO-DD  
INCI  
Preferred Name English
SODIUM CITRATE, UNSPECIFIED FORM
Common Name English
SODIUM CITRATE [II]
Common Name English
SODIUM CITRATE [USP-RS]
Common Name English
SODIUM CITRATE [INCI]
Common Name English
SODIUM CITRATE [USP IMPURITY]
Common Name English
SODIUM CITRATE [ORANGE BOOK]
Common Name English
SODIUM CITRATE [VANDF]
Common Name English
SODIUM CITRATE, UNSPECIFIED
Common Name English
Sodium citrate [WHO-DD]
Common Name English
Trisodium citrate
INCI  
Official Name English
Classification Tree Code System Code
WHO-VATC QB05CB02
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
FDA ORPHAN DRUG 87094
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
NCI_THESAURUS C29730
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
DSLD 3850 (Number of products:9)
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
CFR 21 CFR 184.1751
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
DSLD 2694 (Number of products:90)
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
NCI_THESAURUS C263
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
WHO-ATC B05CB02
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
Code System Code Type Description
EVMPD
SUB12582MIG
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
CHEBI
32142
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
RXCUI
253204
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
CHEBI
53258
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
ChEMBL
CHEMBL1355
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
DAILYMED
1Q73Q2JULR
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
MESH
C514290
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
MESH
C102006
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
NCI_THESAURUS
C62075
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
FDA UNII
1Q73Q2JULR
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
RXCUI
56466
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
ALTERNATIVE
EVMPD
SUB16054MIG
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
WIKIPEDIA
TRISODIUM CITRATE
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
DRUG CENTRAL
4477
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
DRUG BANK
DB09154
Created by admin on Fri Dec 15 16:29:14 UTC 2023 , Edited by admin on Fri Dec 15 16:29:14 UTC 2023
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
ACTIVE MOIETY
Definition References