Stereochemistry | ACHIRAL |
Molecular Formula | C6H6N2O2 |
Molecular Weight | 138.124 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(C=C1)[N+]([O-])=O
InChI
InChIKey=TYMLOMAKGOJONV-UHFFFAOYSA-N
InChI=1S/C6H6N2O2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H,7H2
Molecular Formula | C6H6N2O2 |
Molecular Weight | 138.124 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
P-nitroaniline is a chromogenic molecule that is used as a dyestuff intermediate in industrial applications. In biochemical research, enzyme assays utilize modified aminoacyl or peptidyl p-nitroanilines as substrates. The enzyme catalyzes the release of free p-nitroaniline, which is the basis of the colorimetric determination of the enzyme activity. Applications of the colorimetric properties of p-nitroanilide include the design of biopolymer drug delivery systems and of solid supports for enzyme immobilization. A kinetic analysis of the α-chymotrypsin catalyzed hydrolysis of aminoacyl and peptidyl p-nitroanilide substrates in vesicles has been reported. It has been shown to possess anti-leishmanial activity.
Approval Year
PubMed
Patents
Sample Use Guides
In a Balb/c mice model of L. Infantum, administration of P-nitroaniline (5mg/kg/day for 10 days, injected ip route) led to a clear-cut parasite burden reduction (ca. 99%).
Route of Administration:
Intraperitoneal