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Other

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Leishmania infantum

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Unknown

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Leishmaniasis

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Curative

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Chemical

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ACETONYLACETONE

C0Z8884J3P

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

p-Nitroaniline

1MRQ0QZG7G

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Leishmania infantum

Conditions:

P-nitroaniline is a chromogenic molecule that is used as a dyestuff intermediate in industrial applications. In biochemical research, enzyme assays utilize modified aminoacyl or peptidyl p-nitroanilines as substrates. The enzyme catalyzes the release...

of free p-nitroaniline, which is the basis of the colorimetric determination of the enzyme activity. Applications of the colorimetric properties of p-nitroanilide include the design of biopolymer drug delivery systems and of solid supports for enzyme immobilization. A kinetic analysis of the α-chymotrypsin catalyzed hydrolysis of aminoacyl and peptidyl p-nitroanilide substrates in vesicles has been reported. It has been shown to possess anti-leishmanial activity.

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