Stereochemistry | ABSOLUTE |
Molecular Formula | C19H18O11 |
Molecular Weight | 422.3396 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C2=C(O)C3=C(OC4=C(C=C(O)C(O)=C4)C3=O)C=C2O
InChI
InChIKey=AEDDIBAIWPIIBD-ZJKJAXBQSA-N
InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1
Molecular Formula | C19H18O11 |
Molecular Weight | 422.3396 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Mangiferin, a bioactive compound derived primarily from Anacardiaceae and Gentianaceae families and found in mangoes and honeybush tea, has been extensively studied for its therapeutic properties. Mangiferin has shown promising chemotherapeutic and chemopreventative potential. In traditional medicine, different cultures have cultivated and processed mangiferin rich plants for the treatment of a range of illnesses including cardiovascular disease, diabetes, infection and cancer. Mangiferin is primarily implicated in down-regulating inflammation, causing cell cycle arrest, reducing proliferation/metastasis, promoting apoptosis in malignant cells and protecting against oxidative stress and DNA damage. Mangiferin also enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria.
CNS Activity
Approval Year
Doses
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
Drug as perpetrator
Sourcing
Sample Use Guides
Mouse tumor xenograft model: Mangiferin (10, 50 and 100 mg/kg) was intraperitoneally injected into the
mice, and the therapy lasted for 2 weeks
Route of Administration:
Intraperitoneal
Mangiferin (30–300 uM), isolated from A. asphodeloides, specifi-
cally inhibited MMP-9 gene expression in PMA-stimulated
human astroglioma U87MG, U373MG, and CRT-MG cells. Mangiferin (80 uM) could inhibit the proliferation of HL-60, block
the cell cycle progression in G2/M phase, and significantly
increased the expressions of CDC2 mRNA and Cyclin B1 mRNA
of HL-60 cells.