PIQUIZIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H26N4O4
Molecular Weight	374.4341
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1OC)C(=NC=N2)N3CCN(CC3)C(=O)OCC(C)C

InChI

InChIKey=NXVJUZJOJFBHLG-UHFFFAOYSA-N

InChI=1S/C19H26N4O4/c1-13(2)11-27-19(24)23-7-5-22(6-8-23)18-14-9-16(25-3)17(26-4)10-15(14)20-12-21-18/h9-10,12-13H,5-8,11H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C19H26N4O4
Molecular Weight	374.4341
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4946165 | https://www.ncbi.nlm.nih.gov/pubmed/4918540 | DOI: 10.1016/S0065-7743(08)60804-0 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 992, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. It has been shown to be equal in activity to a combination of theophylline, ephedrine and phenobarbital. Piquizil and Tedral were equally effective in the management of asthmatic patients.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
smooth muscle contraction 13 Target ID: GO:0006939 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4946165 \| https://www.ncbi.nlm.nih.gov/pubmed/4918540	Inhibitor 8297

PubMed

Title	Date	PubMed
Further observations on respiratory flow-volume loops: clinical evaluation of a new oral bronchodilator, CP-12,521-1.	1970 Sep	4918540
Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators.	1971	4946165

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:21:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:21:18 GMT 2023`
Record UNII	1K46616F1O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIQUIZIL

Official Name

English

piquizil [INN]

Common Name

English

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-METHYLPROPYL ESTER

Common Name

English

Code System Code Type Description

INN

2633