PIQUIZIL HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H26N4O4.ClH
Molecular Weight	410.895
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC2=C(C=C1OC)C(=NC=N2)N3CCN(CC3)C(=O)OCC(C)C

InChI

InChIKey=JHTJRGPKVWEJOA-UHFFFAOYSA-N

InChI=1S/C19H26N4O4.ClH/c1-13(2)11-27-19(24)23-7-5-22(6-8-23)18-14-9-16(25-3)17(26-4)10-15(14)20-12-21-18;/h9-10,12-13H,5-8,11H2,1-4H3;1H

HIDE SMILES / InChI

Molecular Formula	C19H26N4O4
Molecular Weight	374.4341
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4946165 | https://www.ncbi.nlm.nih.gov/pubmed/4918540 | DOI: 10.1016/S0065-7743(08)60804-0 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 992, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. It has been shown to be equal in activity to a combination of theophylline, ephedrine and phenobarbital. Piquizil and Tedral were equally effective in the management of asthmatic patients.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
smooth muscle contraction 13 Target ID: GO:0006939 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4946165 \| https://www.ncbi.nlm.nih.gov/pubmed/4918540	Inhibitor 8297

PubMed

Title	Date	PubMed
Further observations on respiratory flow-volume loops: clinical evaluation of a new oral bronchodilator, CP-12,521-1.	1970 Sep	4918540
Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators.	1971	4946165

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:12:44 GMT 2023` Edited by `admin` on `Sat Dec 16 05:12:44 GMT 2023`
Record UNII	K4J5215PFO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIQUIZIL HYDROCHLORIDE

Official Name

English

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-METHYLPROPYL ESTER, MONOHYDROCHLORIDE

Common Name

English

CP-12,521-1

Code

English

Isobutyl 4-(6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylate monohydrochloride

Systematic Name

English

CP-12521-1

Code

English

PIQUIZIL HCL

Common Name

English

PIQUIZIL HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319