SODIUM COPPER CHLOROPHYLLIN

Description

Chlorophyllin is a water soluble derivative of chlorophyll. It has chemopreventive properties and forms a non-covalent complex with many mutagenic/carcinogenic molecules. Chlorophyllin inhibits cancer initiation and progression by targeting multiple molecules and pathways involved in the metabolism of carcinogens, cell cycle progression, apoptosis evasion, invasion, and angiogenesis. The modulatory effects of Chlorophyllin to be mediated via abrogation of key oncogenic signal transduction pathways such as nuclear factor kappa B, Wnt/β-catenin, and phosphatidylinositol-3-kinase/Akt signaling. Chlorophyllin sodium copper salt mitigates radiation-induced hematopoietic syndrome by increasing the abundance of hematopoietic stem cells, enhancing granulopoiesis, and stimulating prosurvival pathways in bone marrow cells and lymphocytes. In addition, chlorophyllin exhibits antioxidant, antiapoptotic and immunostimulatory effects. Chlorophyllin is intended to improve the quality of life in people who have fecal incontinence due to spinal cord injury, bowel cancer, psychotic disorder, terminal illness, or other disorders. Chlorophyllin is also used by people who have had a colostomy or ileostomy

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
hemopoiesis 1	Modulator 828
platelet aggregation 76	Inhibitor 8,297

Conditions

Condition	Modality	Highest Phase	Product
Radiation-induced hematopoietic syndrome 1	Palliative	Not Provided 504	Unknown
Cancer 592	Primary	Preclinical	Unknown
Fecal incontinence 3	Palliative	Approved 8,429	Derifil

Doses

Doses

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Dose	Population	Adverse events
40 mg 3 times / day multiple, oral Studied dose	unhealthy, ADULT

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PubMed

Show entries

Title	Date	PubMed
Effect of chlorophyllin on urinary odor in incontinent geriatric patients.	1983 Oct	6628224
Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1.	1994 Apr 15	8164251
A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody.	1999 Jun	10403680
[Targeting of chlorine E6 by EGF increasing its photodynamic activity in selective ways].	2000	11004908
Interaction of porphyrins with human organic anion transporting polypeptide 1B1.	2009 Nov 10	19560444

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Patents

Sample Use Guides

In Vivo Use Guide

urinary odor: each patient received chlorophyllin 100 mg/d for two weeks and placebo daily for two weeks, separated by a washout period of one week.

Route of Administration: Oral

In Vitro Use Guide

It was investigated the effects on cell proliferation and the expression of genes involved in apoptosis, and the cell cycle in HB4a cells treated with Chlorophyllin (Chl). Chl was cytotoxic and induced apoptosis to HB4a cells at 400 μg/mL. Analysis of gene expression showed that there was a decrease in the mRNA level of BIRC5 and CCNA2 genes involved in apoptosis and cell cycle progression, respectively. The proapoptotic gene BAX and the antiapoptotic genes BCL-2 and BCL-XL were upregulated. The cytotoxicity of Chl has been attributed to increases in the expression of BAX and decreases in the expression of genes involved in the cell cycle, but increases in the expression of anti-apoptotic genes suggests a mechanism for protection from cell death induced by Chl.