U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 15:01:51 GMT 2023
Edited
by admin
on Sat Dec 16 15:01:51 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
1921J8Y305
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18
Common Name English
TNFRSF18
Common Name English
CD_ANTIGEN: CD357
Common Name English
GITR
Common Name English
ACTIVATION-INDUCIBLE TNFR FAMILY RECEPTOR
Common Name English
AITR
Common Name English
GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN
Common Name English
Code System Code Type Description
UNIPROT
Q9Y5U5
Created by admin on Sat Dec 16 15:01:51 GMT 2023 , Edited by admin on Sat Dec 16 15:01:51 GMT 2023
PRIMARY
FDA UNII
1921J8Y305
Created by admin on Sat Dec 16 15:01:51 GMT 2023 , Edited by admin on Sat Dec 16 15:01:51 GMT 2023
PRIMARY
WIKIPEDIA
TNFRSF18
Created by admin on Sat Dec 16 15:01:51 GMT 2023 , Edited by admin on Sat Dec 16 15:01:51 GMT 2023
PRIMARY
PHAROS
Q9Y5U5
Created by admin on Sat Dec 16 15:01:51 GMT 2023 , Edited by admin on Sat Dec 16 15:01:51 GMT 2023
PRIMARY
From To
1_9 1_24
1_49 1_61
1_56 1_69
1_90 1_109
1_103 1_128
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_121
Related Record Type Details
AGONIST -> TARGET
INHIBITOR -> TARGET
ACTIVATOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Binds to and activates GITRs found on multiple types of T-cells. This stimulates the immune system, induces both the activation and proliferation of tumor-antigen-specific T effector cells (Teff), and suppresses the function of activated T regulatory cells (Tregs).
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL