RAGIFILIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:07:07 GMT 2025` Edited by `admin` on `Wed Apr 02 01:07:07 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	O440IW9NHN
Record Status	`FAILED`
Record Version

Download

Name

Type

Language

RAGIFILIMAB

Official Name

English

INCAGN-01876

Preferred Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS TNFRSF18 (TUMOR NECROSIS FACTOR RECEPTOR (TNFR) SUPERFAMILY MEMBER 18, ACTIVATION-INDUCIBLE TNFR FAMILY RECEPTOR, AITR, GLUCOCORTICOID-INDUCED TNFR-RELATED, GITR, CD375)), HUMANIZED MONOCLONAL ANTIBODY; GAMMA1

Common Name

English

IMMUNOGLOBULIN G1 (DE-448-LYSINE), ANTI-(HUMAN TUMOR NECROSIS FACTOR RECEPTOR TNFRSF18) (HUMAN-MUS MUSCULUS MONOCLONAL INCAGN01876.GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL INCAGN01876 .KAPPA.-CHAIN, DIMER

Common Name

English

ANTI-GITR AGONISTIC MONOCLONAL ANTIBODY INCAGN01876

Common Name

English

CM701

Code

English

ragifilimab [INN]

Common Name

English

AGEN-1876

Code

English

AGEN1876

Code

English

CM-701

Code

English

INCAGN01876

Code

English

RAGIFILIMAB [USAN]

Common Name

English

Ragifilimab [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C129822

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

NCI_THESAURUS

C128058

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

Code System Code Type Description

SMS_ID

300000024159

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

PRIMARY

NCI_THESAURUS

C126643

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

PRIMARY

CAS

2207590-51-8

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

PRIMARY

INN

11280

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

PRIMARY

FDA UNII

O440IW9NHN

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

PRIMARY

USAN

JK-153

Created by admin on Wed Apr 02 01:07:07 GMT 2025 , Edited by admin on Wed Apr 02 01:07:07 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_220
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200
1_221	3_220
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					1921J8Y305

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18

TARGET -> AGONIST

Amount:

Related Record Type Details


					O440IW9NHN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL