Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone. Felypressin is added to some local anesthetics such as prilocaine in a concentration of 0.03 IU/ml. Its antidiuretic effects are less than those of vasopressin. Felypressin is used as a vasoconstrictor in local anesthetic injections for dental use and is an ingredient of preparations that have been used for the treatment of pain and inflammation of the mouth.
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Approval Year
PubMed
Patents
Sample Use Guides
Adult: As combination containing prilocaine hydrochloride 30 mg and felypressin 0.03 IU/ml: Usual dose: 1-5 ml, adjust according to response. Max: 10 ml.
Child: As combination containing prilocaine hydrochloride 30 mg and felypressin 0.03 IU/ml: <10 yr: 1-2 ml; 10-18 yr: 1-5 ml, max 10ml. Adjust dose according to response.
Route of Administration:
Intramuscular
Adenohypophyses, removed from decapitated rats, were divided into four segments of approximately equal size and incubated together for 150 min at 37 °C in 2-0 ml medium, ionically similar to cerebrospinal fluid containing ascorbic acid (1 mmol/1; pH 7-4), through which 95% O2 / 5% CO2 was passed continually. The medium was replaced after 120 and 135 min. The pituitary segments were then separated and incubated for a further 15 min, either in medium (1-0 ml) con¬ taining vasopressin-receptor agonist Felypressin and/or CRF-41 or in a corresponding volume of medium alone (controls). The medium was stored at
-30 °C and its ACTH concentration determined subsequently
Subunit 0
