U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2O.Ti
Molecular Weight 79.866
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TITANIUM DIOXIDE

SMILES

[O--].[O--].[Ti+4]

InChI

InChIKey=SOQBVABWOPYFQZ-UHFFFAOYSA-N
InChI=1S/2O.Ti/q2*-2;+4

HIDE SMILES / InChI

Molecular Formula O
Molecular Weight 15.9994
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Ti
Molecular Weight 47.867
Charge 4
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022009s000_ClinPharmR.pdf | https://www.ncbi.nlm.nih.gov/pubmed/18503414

Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium, chemical formula TiO 2. When used as a pigment, it is called titanium white, Pigment White 6 (PW6), or CI 77891. Generally it is sourced from ilmenite, rutile and anatase. It has a wide range of applications, from paint to sunscreen to food coloring. When used as a food coloring, it has E number E171. World production in 2014 exceeded 9 million metric tons. Titanium dioxide has excellent ultraviolet (UV) resistant qualities and acts as a UV absorbent. In the pharmaceutical industry, titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups. In the cosmetics industry, it is used in toothpaste, lipsticks, creams, ointments and powders. It can be used as an opacifier to make pigments opaque. The FDA has approved the safety of titanium dioxide for use as a colorant in food, drugs and cosmetics, including sunscreens. However, controversy exists as to the safety of titanium dioxide nanoparticles used in the cosmetics industry, for example in sunscreens. Titanium and zinc oxides may be made into the nanoparticle size (0.2-100 nanometers) to reduce the white appearance when applied topically, but retain the UV blocking properties. Recent studies suggest titanium dioxide nanoparticles may be toxic, although further research is needed.

CNS Activity

Curator's Comment: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022009s000_ClinPharmR.pdf

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: ultraviolet induced damage
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
ANTHELIOS 40

Approved Use

Unknown

Launch Date

1.20692159E12
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals.
1994 Mar
Cytokine and prostaglandin E2 release from leukocytes in response to metal ions derived from different prosthetic materials: an in vitro study.
1999 Dec
Matrix metalloproteinases MMP-2, -9 and tissue inhibitors TIMP-1, -2 expression and secretion by primary human osteoblast cells in response to titanium, zirconia, and alumina ceramics.
2004 Jan 1
Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility.
2008 Jan
Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion.
2009 Dec 15
Role of air pollution Particulate Matter (PM(2.5)) in the occurrence of loss of heterozygosity in multiple critical regions of 3p chromosome in human epithelial lung cells (L132).
2009 Jun 22
The effects of implant surface nanoscale features on osteoblast-specific gene expression.
2009 Sep
Titanium dioxide nanoparticles cause apoptosis in BEAS-2B cells through the caspase 8/t-Bid-independent mitochondrial pathway.
2010 Jun 16
Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules.
2010 Jun 2
Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less.
2010 Sep
DNA damage and alterations in expression of DNA damage responsive genes induced by TiO2 nanoparticles in human hepatoma HepG2 cells.
2011 Sep
Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells.
2013 Apr 5
Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue.
2014 Dec 9
Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation.
2014 Jul 1
Sheet-type titania, but not P25, induced paraptosis accompanying apoptosis in murine alveolar macrophage cells.
2014 Oct 1
Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae.
2015 Apr
Titanium dioxide nanoparticles modulate the toxicological response to cadmium in the gills of Mytilus galloprovincialis.
2015 Oct 30
Patents

Sample Use Guides

Apply evenly 15 minutes before sun exposure. Reapply as needed or after towel drying, swimming, or perspiring. Children under 6 months of age, ask a doctor.
Route of Administration: Topical
For the in vitro studies, the stratum corneum side of the skin was in contact with either the aqueous or oily commercial dispersion of microfine TiO2 (150 μl/cm^2). The dermis side was placed onto a tissue of cellulose soaked with isotonic phosphate buffered saline (PBS) of pH 7.4. Twenty-four hours after application of the dispersion, the PBS was removed from the skin with a dry paper towel. For the in vivo studies, 2 μl cm−2 of the commercial dispersions and the different formulations were applied onto the ventral side of the forearm of a healthy female volunteer. After 45 min, any dispersion or formulation that had not penetrated the skin was also removed with a paper towel. All penetration tests were performed in triplicate.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:38:43 UTC 2023
Edited
by admin
on Fri Dec 15 15:38:43 UTC 2023
Record UNII
15FIX9V2JP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TITANIUM DIOXIDE
EP   FCC   HSDB   II   INCI   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
TITANIUM DIOXIDE [INCI]
Common Name English
CI 77891
INCI  
INCI  
Official Name English
TITANIUM DIOXIDE [MART.]
Common Name English
C.I. 77891
Common Name English
TITANIUM DIOXIDE [USP MONOGRAPH]
Common Name English
TITANIUM DIOXIDE [EP MONOGRAPH]
Common Name English
CI 77891 [INCI]
Common Name English
TITANIUM DIOXIDE [USP-RS]
Common Name English
CI-(1975)NO.77891
Code English
CI-PIGMENT WHITE 6
Common Name English
TITANIA
Common Name English
TITANIUM OXIDE
Common Name English
INS-171
Code English
SAGENITE
Common Name English
TITANIUM OXIDE [JAN]
Common Name English
TITANIUM DIOXIDE [MI]
Common Name English
INS NO.171
Code English
TITANIUM DIOXIDE [VANDF]
Common Name English
TITANIUM DIOXIDE [ORANGE BOOK]
Common Name English
NSC-15204
Code English
TITANIUM DIOXIDE [FCC]
Common Name English
E 171
Code English
TITANIUM DIOXIDE [II]
Common Name English
NSC-200C
Code English
RUTILE
Common Name English
RUTILE (TIO2)
Common Name English
Titanium dioxide [WHO-DD]
Common Name English
TITANIUM DIOXIDE [HSDB]
Common Name English
TITANIUM DIOXIDE [EP IMPURITY]
Common Name English
CI-77891
Common Name English
TITANIUM DIOXIDE [IARC]
Common Name English
E-171
Code English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-171
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
CFR 21 CFR 178.3297
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
NCI_THESAURUS C461
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
DSLD 1166 (Number of products:1)
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 38
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
FDA ORPHAN DRUG 199204
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 575
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
JECFA EVALUATION INS-171
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
CFR 21 CFR 352.20
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
CFR 21 CFR 175.210
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
EU-Orphan Drug EU/3/05/262
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
EPA PESTICIDE CODE NOT YET ASSIGNED
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 576
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
CFR 21 CFR 352.10
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
FDA ORPHAN DRUG 142401
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 577
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
Code System Code Type Description
EVMPD
SUB12611MIG
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
HSDB
869
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
NCI_THESAURUS
C61975
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
MESH
C009495
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
DRUG BANK
DB09536
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
EPA CompTox
DTXSID3021352
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
RS_ITEM_NUM
1667585
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
DRUG CENTRAL
4237
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
CAS
1317-80-2
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
ALTERNATIVE
PUBCHEM
162651
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
CHEBI
46748
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
CAS
13463-67-7
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
RXCUI
38323
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY RxNorm
FDA UNII
15FIX9V2JP
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
WIKIPEDIA
TITANIUM DIOXIDE
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
CHEBI
32234
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
CHEBI
134438
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
ECHA (EC/EINECS)
236-675-5
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
DAILYMED
15FIX9V2JP
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
CAS
1344-29-2
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
ALTERNATIVE
MERCK INDEX
m10898
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY Merck Index
SMS_ID
100000092217
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
ChEMBL
CHEMBL1201136
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
ECHA (EC/EINECS)
215-282-2
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
ALTERNATIVE
NSC
15204
Created by admin on Fri Dec 15 15:38:43 UTC 2023 , Edited by admin on Fri Dec 15 15:38:43 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY