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Details

Stereochemistry ABSOLUTE
Molecular Formula C8H15NO3
Molecular Weight 173.2096
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SCH-50911 FREE BASE

SMILES

CC1(C)CO[C@@H](CC(O)=O)CN1

InChI

InChIKey=SEYCKMQSPUVYEF-LURJTMIESA-N
InChI=1S/C8H15NO3/c1-8(2)5-12-6(4-9-8)3-7(10)11/h6,9H,3-5H2,1-2H3,(H,10,11)/t6-/m0/s1

HIDE SMILES / InChI

Molecular Formula C8H15NO3
Molecular Weight 173.2096
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1100.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.
1995 Sep
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.
1995 Sep
Modification of d-amphetamine-induced responses by baclofen in rats.
2001 Jan
Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid.
2001 Oct 12
Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits.
2003 Apr 1
Up-regulation of GABA(B) receptors by chronic administration of the GABA(B) receptor antagonist SCH 50,911.
2005 May 16
Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination.
2007 Nov 28
Gamma-aminobutyric acidB (GABAB)-receptor mediation of different in vivo effects of gamma-butyrolactone.
2008 Feb
Substance Class Chemical
Created
by admin
on Sat Dec 16 02:07:09 GMT 2023
Edited
by admin
on Sat Dec 16 02:07:09 GMT 2023
Record UNII
13OB0KEU61
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SCH-50911 FREE BASE
Common Name English
SCH 50911 FREE BASE
Code English
2-MORPHOLINEACETIC ACID, 5,5-DIMETHYL-, (2S)-
Common Name English
Code System Code Type Description
PUBCHEM
5311429
Created by admin on Sat Dec 16 02:07:09 GMT 2023 , Edited by admin on Sat Dec 16 02:07:09 GMT 2023
PRIMARY
CAS
733717-87-8
Created by admin on Sat Dec 16 02:07:09 GMT 2023 , Edited by admin on Sat Dec 16 02:07:09 GMT 2023
PRIMARY
FDA UNII
13OB0KEU61
Created by admin on Sat Dec 16 02:07:09 GMT 2023 , Edited by admin on Sat Dec 16 02:07:09 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT