SCH-50911

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H15NO3.ClH
Molecular Weight	209.671
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1(C)CO[C@@H](CC(O)=O)CN1

InChI

InChIKey=QYYBBASPKHNBKA-RGMNGODLSA-N

InChI=1S/C8H15NO3.ClH/c1-8(2)5-12-6(4-9-8)3-7(10)11;/h6,9H,3-5H2,1-2H3,(H,10,11);1H/t6-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C8H15NO3
Molecular Weight	173.2096
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-B receptor 32 Target ID: CHEMBL2111463 Sources: https://www.sciencedirect.com/science/article/pii/S0960894X96002673	Antagonist 2849		1100.0 nM [IC50]

PubMed

Title	Date	PubMed
Gamma-aminobutyric acidB (GABAB)-receptor mediation of different in vivo effects of gamma-butyrolactone.	2008-02	18270475
Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination.	2007-11-28	17698060
Effects of GABA(B) receptor agents on cocaine priming, discrete contextual cue and food induced relapses.	2007-10-01	17610868
Resuscitative treatments on 1,4-butanediol mortality in mice.	2006-02	16431232
Up-regulation of GABA(B) receptors by chronic administration of the GABA(B) receptor antagonist SCH 50,911.	2005-05-16	15893746
Gamma-hydroxybutyric acid (GHB) and the mesoaccumbens reward circuit: evidence for GABA(B) receptor-mediated effects.	2005	15708487
Protection by the GABAB receptor antagonist, SCH 50911, of gamma-hydroxybutyric acid-induced mortality in mice.	2004-10-25	15496299
3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release.	2004-09	15322240
Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits.	2003-04-01	12663046
Proconvulsive effect of the GABA(B) receptor antagonist, SCH 50911, in rats undergoing ethanol withdrawal syndrome.	2002-06-12	12079684
Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid.	2002-04-26	12063087
GABA(B) receptor inhibition causes locomotor stimulation in mice.	2001-12-14	11755139
gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors.	2001-11-02	11711039
Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid.	2001-10-12	11689189
Modification of d-amphetamine-induced responses by baclofen in rats.	2001-01	11271399
The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.	2000-11	11082110
Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.	1995-09	7562514
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.	1995-09	7562513

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:07:07 GMT 2025` Edited by `admin` on `Mon Mar 31 21:07:07 GMT 2025`
Record UNII	Q5MMG73452
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SCH 50911

Preferred Name

English

SCH-50911

Common Name

English

2-MORPHOLINEACETIC ACID, 5,5-DIMETHYL-, HYDROCHLORIDE (1:1), (2S)-

Common Name

English

2-MORPHOLINEACETIC ACID, 5,5-DIMETHYL-, HYDROCHLORIDE, (2S)-

Common Name

English

Code System Code Type Description

PUBCHEM

10130513