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Details

Stereochemistry ABSOLUTE
Molecular Formula C8H15NO3.ClH
Molecular Weight 209.671
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SCH-50911

SMILES

Cl.CC1(C)CO[C@@H](CC(O)=O)CN1

InChI

InChIKey=QYYBBASPKHNBKA-RGMNGODLSA-N
InChI=1S/C8H15NO3.ClH/c1-8(2)5-12-6(4-9-8)3-7(10)11;/h6,9H,3-5H2,1-2H3,(H,10,11);1H/t6-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C8H15NO3
Molecular Weight 173.2096
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1100.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models.
1995 Sep
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.
1995 Sep
GABA(B) receptor inhibition causes locomotor stimulation in mice.
2001 Dec 14
Protection by the GABAB receptor antagonist, SCH 50911, of gamma-hydroxybutyric acid-induced mortality in mice.
2004 Oct 25
3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release.
2004 Sep
Gamma-hydroxybutyric acid (GHB) and the mesoaccumbens reward circuit: evidence for GABA(B) receptor-mediated effects.
2005
Up-regulation of GABA(B) receptors by chronic administration of the GABA(B) receptor antagonist SCH 50,911.
2005 May 16
Resuscitative treatments on 1,4-butanediol mortality in mice.
2006 Feb
Effects of GABA(B) receptor agents on cocaine priming, discrete contextual cue and food induced relapses.
2007 Oct 1
Substance Class Chemical
Created
by admin
on Sat Dec 16 02:02:49 GMT 2023
Edited
by admin
on Sat Dec 16 02:02:49 GMT 2023
Record UNII
Q5MMG73452
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SCH-50911
Common Name English
SCH 50911
Code English
2-MORPHOLINEACETIC ACID, 5,5-DIMETHYL-, HYDROCHLORIDE (1:1), (2S)-
Common Name English
2-MORPHOLINEACETIC ACID, 5,5-DIMETHYL-, HYDROCHLORIDE, (2S)-
Common Name English
Code System Code Type Description
PUBCHEM
10130513
Created by admin on Sat Dec 16 02:02:49 GMT 2023 , Edited by admin on Sat Dec 16 02:02:49 GMT 2023
PRIMARY
EPA CompTox
DTXSID0045670
Created by admin on Sat Dec 16 02:02:49 GMT 2023 , Edited by admin on Sat Dec 16 02:02:49 GMT 2023
PRIMARY
CAS
160415-07-6
Created by admin on Sat Dec 16 02:02:49 GMT 2023 , Edited by admin on Sat Dec 16 02:02:49 GMT 2023
PRIMARY
FDA UNII
Q5MMG73452
Created by admin on Sat Dec 16 02:02:49 GMT 2023 , Edited by admin on Sat Dec 16 02:02:49 GMT 2023
PRIMARY
MESH
C095804
Created by admin on Sat Dec 16 02:02:49 GMT 2023 , Edited by admin on Sat Dec 16 02:02:49 GMT 2023
PRIMARY
WIKIPEDIA
SCH-50911
Created by admin on Sat Dec 16 02:02:49 GMT 2023 , Edited by admin on Sat Dec 16 02:02:49 GMT 2023
PRIMARY
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PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY