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Details

Stereochemistry ACHIRAL
Molecular Formula C15H22N2O3
Molecular Weight 278.3468
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLYCAINE

SMILES

CCN(CC)CC(=O)NC1=C(C)C=CC=C1C(=O)OC

InChI

InChIKey=UDKICLZCJWQTLS-UHFFFAOYSA-N
InChI=1S/C15H22N2O3/c1-5-17(6-2)10-13(18)16-14-11(3)8-7-9-12(14)15(19)20-4/h7-9H,5-6,10H2,1-4H3,(H,16,18)

HIDE SMILES / InChI
Molecular Formula C15H22N2O3
Molecular Weight 278.3468
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Tolycaine hydrochloride is an amide local anaesthetic included in some preparations to reduce the pain of injection. It can be used for dental injection.

CNS Activity

CNS Active
4,002

Originator

ZYF Pharm Chemical
16

Approval Year

Unknown
149,124

Targets

Primary TargetPharmacologyConditionPotency
Small intestinal methyl leucine uptake
2
Inhibitor
8,504
Small intestinal methyl a-D-glucoside uptake
2
Inhibitor
8,504

Conditions

ConditionModalityTargetsHighest PhaseProduct
Pain
619
 Palliative
Preclinical
Unknown

PubMed

Patents

US2015306170
2
US2015352251
2
US2016030408
7

Sample Use Guides

In Vivo Use Guide
Maximal dose - 250 mg for anorectal surgery
Route of Administration: Intramuscular
In Vitro Use Guide
5mM/l of Tolycaine inhibited 57% of control leucine uptake by rat jejunum
Substance Class Chemical
Record UNII
12R8659YM6
Record Status Validated (UNII)
Record Version
NIH
NCATS
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