TOLYCAINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H22N2O3.ClH
Molecular Weight	314.808
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C(=O)OC

InChI

InChIKey=LIWOWASNSWUKPF-UHFFFAOYSA-N

InChI=1S/C15H22N2O3.ClH/c1-5-17(6-2)10-13(18)16-14-11(3)8-7-9-12(14)15(19)20-4;/h7-9H,5-6,10H2,1-4H3,(H,16,18);1H

HIDE SMILES / InChI

Molecular Formula	C15H22N2O3
Molecular Weight	278.3468
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01878
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/9000257

Tolycaine hydrochloride is an amide local anaesthetic included in some preparations to reduce the pain of injection. It can be used for dental injection.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Small intestinal methyl leucine uptake 2 Target ID: Small intestinal methyl leucine uptake Sources: http://www.ncbi.nlm.nih.gov/pubmed/10692555	Inhibitor 8297
Small intestinal methyl a-D-glucoside uptake 2 Target ID: Small intestinal methyl a-D-glucoside uptake Sources: http://www.ncbi.nlm.nih.gov/pubmed/10692555	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2489796	Palliative		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Pharmacological analysis of local anaesthetic tolycaine-induced convulsions by modification of monoamines in rat brain.	1996 Dec	9000257
Active transport inhibition in rat small intestine by amphiphilic amines: an in vitro study with various local anaesthetics.	2000 Apr 15	10692555

Patents

Sample Use Guides

In Vivo Use Guide

Maximal dose - 250 mg for anorectal surgery

Route of Administration: Intramuscular

In Vitro Use Guide

5mM/l of Tolycaine inhibited 57% of control leucine uptake by rat jejunum

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:07:03 GMT 2023` Edited by `admin` on `Fri Dec 15 19:07:03 GMT 2023`
Record UNII	23212OEY8I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TOLYCAINE HYDROCHLORIDE

Common Name

English

TOLYCAINE HYDROCHLORIDE [MI]

Common Name

English

Tolycaine hydrochloride [WHO-DD]

Common Name

English

2-(2-(DIETHYLAMINO)ACETAMIDO)-M-TOLUIC ACID METHYL ESTER MONOHYDROCHLORIDE

Systematic Name

English

TOLYCAINE HYDROCHLORIDE [JAN]

Common Name

English

Code System Code Type Description

MERCK INDEX

m10970