Praxadine

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H6N4
Molecular Weight	110.1172
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)N1C=CC=N1

InChI

InChIKey=UCQFSGCWHRTMGG-UHFFFAOYSA-N

InChI=1S/C4H6N4/c5-4(6)8-3-1-2-7-8/h1-3H,(H3,5,6)

HIDE SMILES / InChI

Molecular Formula	C4H6N4
Molecular Weight	110.1172
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9278100 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1044, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | (1993) Progress in Medicinal Chemistry, v.30, page 259, retrieved from: https://books.google.ru/books?id=ngLUHsfpbJUC

Praxadine is the anti-inflammatory and analgesic agent. Praxadine inhibited the activity of purified inducible NOS (iNOS), endothelial NOS (eNOS), and neuronal NOS (nNOS) isoforms to a similar extent.

Approval Year

PubMed

Title	Date	PubMed
Solid-phase guanidinylation of peptidyl amines compatible with standard Fmoc-chemistry: formation of monosubstituted guanidines.	2013	24014439

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:54:45 GMT 2023` Edited by `admin` on `Sat Dec 16 15:54:45 GMT 2023`
Record UNII	12L58GX4AS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Praxadine

Official Name

English

1H-Pyrazole-1-carboximidamide

Systematic Name

English

praxadine [INN]

Common Name

English

ZANAMIVIR HYDRATE IMPURITY F [EP IMPURITY]

Common Name

English

Pyrazole-1-carboxamidine

Systematic Name

English

1-Amidinopyrazole

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29396