Praxadine hydrochloride

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H6N4.ClH
Molecular Weight	146.578
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC(=N)N1C=CC=N1

InChI

InChIKey=RBZRMBCLZMEYEH-UHFFFAOYSA-N

InChI=1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H6N4
Molecular Weight	110.1172
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9278100 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1044, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | (1993) Progress in Medicinal Chemistry, v.30, page 259, retrieved from: https://books.google.ru/books?id=ngLUHsfpbJUC

Praxadine is the anti-inflammatory and analgesic agent. Praxadine inhibited the activity of purified inducible NOS (iNOS), endothelial NOS (eNOS), and neuronal NOS (nNOS) isoforms to a similar extent.

Approval Year

PubMed

Title	Date	PubMed
Solid-phase guanidinylation of peptidyl amines compatible with standard Fmoc-chemistry: formation of monosubstituted guanidines.	2013	24014439
Guanidylated hollow fiber membranes based on brominated poly (2,6-dimethyl-1,4-phenylene oxide) (BPPO) for gold sorption from acid solutions.	2012-11-30	23046695
Synthesis, X-ray crystal structures, and phosphate ester cleavage properties of bis(2-pyridylmethyl)amine copper(II) complexes with guanidinium pendant groups.	2008-10-06	18754616
Inhibition of nitric oxide synthase with pyrazole-1-carboxamidine and related compounds.	1997-08-01	9278100

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:08:00 GMT 2025` Edited by `admin` on `Mon Mar 31 22:08:00 GMT 2025`
Record UNII	S9X3PXT9NC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-Amidinopyrazole hydrochloride

Preferred Name

English

Praxadine hydrochloride

Common Name

English

1H-Pyrazole-1-carboximidamide, monohydrochloride

Systematic Name

English

1H-Pyrazole-1-carboximidamide, hydrochloride (1:1)

Systematic Name

English

Pyrazole-1-carboxamidine, hydrochloride

Systematic Name

English

Pyrazole-1-carboximidamide hydrochloride

Systematic Name

English

1H-Pyrazole-1-carboxamidine monohydrochloride

Systematic Name

English

1H-Pyrazole-1-carboxamidine hydrochloride

Systematic Name

English

Code System Code Type Description

PUBCHEM

2734672

Created by admin on Mon Mar 31 22:08:00 GMT 2025 , Edited by admin on Mon Mar 31 22:08:00 GMT 2025

PRIMARY

FDA UNII

S9X3PXT9NC

Created by admin on Mon Mar 31 22:08:00 GMT 2025 , Edited by admin on Mon Mar 31 22:08:00 GMT 2025

PRIMARY

CAS

4023-02-3

Created by admin on Mon Mar 31 22:08:00 GMT 2025 , Edited by admin on Mon Mar 31 22:08:00 GMT 2025

PRIMARY

EPA CompTox

DTXSID0046517

Created by admin on Mon Mar 31 22:08:00 GMT 2025 , Edited by admin on Mon Mar 31 22:08:00 GMT 2025

PRIMARY

Related Record Type Details


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Praxadine

PARENT -> SALT/SOLVATE

Amount: