U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C17H24N6O4
Molecular Weight 376.4103
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SELODENOSON

SMILES

CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=NC3=C2N=CN=C3NC4CCCC4

InChI

InChIKey=GWVQGVCXFNYGFP-PFHKOEEOSA-N
InChI=1S/C17H24N6O4/c1-2-18-16(26)13-11(24)12(25)17(27-13)23-8-21-10-14(19-7-20-15(10)23)22-9-5-3-4-6-9/h7-9,11-13,17,24-25H,2-6H2,1H3,(H,18,26)(H,19,20,22)/t11-,12+,13-,17+/m0/s1

HIDE SMILES / InChI

Molecular Formula C17H24N6O4
Molecular Weight 376.4103
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Selodenoson (formerly DTI-0009) was developed by Aderis Pharmaceutical as a selective adenosine A1 full agonist to control heart rate in patients with atrial fibrillation while minimizing changes in blood pressure or decreases in heart function. The drug was studied in phase II clinical trial to treat the patients with supraventricular arrhythmias, however, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

In the trial, patients were randomized to receive placebo or selodenoson at 2, 4, 6, 8, 10 or 12 mcg/kg doses as a 15-minute infusion. The heart rate was reduced by all doses at 5, 15 (end of infusion) and 30 minutes after beginning the infusion.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:18:38 GMT 2023
Edited
by admin
on Fri Dec 15 16:18:38 GMT 2023
Record UNII
103G5E953K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SELODENOSON
INN   USAN  
USAN   INN  
Official Name English
selodenoson [INN]
Common Name English
SELODENOSON [USAN]
Common Name English
GR-56072
Code English
DTI-0009
Code English
RG-14202
Code English
Classification Tree Code System Code
NCI_THESAURUS C29707
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
Code System Code Type Description
MESH
C522396
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
PUBCHEM
3082555
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
NCI_THESAURUS
C75135
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
SMS_ID
300000034406
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
CAS
110299-05-3
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107371
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
FDA UNII
103G5E953K
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
USAN
PP-01
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
INN
8466
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
EPA CompTox
DTXSID00149201
Created by admin on Fri Dec 15 16:18:38 GMT 2023 , Edited by admin on Fri Dec 15 16:18:38 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY