DAMOTEPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17NS
Molecular Weight	267.389
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2

InChI

InChIKey=BRCYAOFSVFIBPV-UHFFFAOYSA-N

InChI=1S/C17H17NS/c1-18(2)12-14-11-13-7-3-5-9-16(13)19-17-10-6-4-8-15(14)17/h3-11H,12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H17NS
Molecular Weight	267.389
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://patents.google.com/patent/GB1080979A/en | https://www.ncbi.nlm.nih.gov/pubmed/4679064

Damotepine is a derivative of thiepin, structurally related to doxepin. Damotepine was discovered by the Swiss pharmaceutical company Geigy A.G. and was evaluated in clinical trials for the treatment of anxiety in the early 1970s.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Study on the associated effects of ethyl alcohol and N,N-dimethyl-dibenzo(b,f)thiepin-10-methylamine-hydrochloride (GP 41299) in the mouse].	1972 Jun	5068355
[Effect of ethyl alcohol on pharmacokinetics of N,N-dimethyl-dibenzo(b,f)thiepine-10-methylamine-hydrochloride (GP 41 299) in man].	1972 May	5068214
Determination of N,N-dimethyldibenzo(b,f)thiepin-10-methylamine by gas-liquid chromatography.	1973 Oct 10	4585208

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:09:54 GMT 2023` Edited by `admin` on `Sat Dec 16 17:09:54 GMT 2023`
Record UNII	0V9VL751XU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DAMOTEPINE

Official Name

English

N,N-DIMETHYLDIBENZO(B,F)THIEPIN-10-METHYLAMINE

Systematic Name

English

damotepine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29756