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Details

Stereochemistry ACHIRAL
Molecular Formula C17H17NS.ClH
Molecular Weight 303.85
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAMOTEPINE HYDROCHLORIDE

SMILES

Cl.CN(C)CC1=CC2=CC=CC=C2SC3=CC=CC=C13

InChI

InChIKey=OXCDWSYLPNFXHP-UHFFFAOYSA-N
InChI=1S/C17H17NS.ClH/c1-18(2)12-14-11-13-7-3-5-9-16(13)19-17-10-6-4-8-15(14)17;/h3-11H,12H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula C17H17NS
Molecular Weight 267.389
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Damotepine is a derivative of thiepin, structurally related to doxepin. Damotepine was discovered by the Swiss pharmaceutical company Geigy A.G. and was evaluated in clinical trials for the treatment of anxiety in the early 1970s.

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Determination of N,N-dimethyldibenzo(b,f)thiepin-10-methylamine by gas-liquid chromatography.
1973-10-10
[Study on the associated effects of ethyl alcohol and N,N-dimethyl-dibenzo(b,f)thiepin-10-methylamine-hydrochloride (GP 41299) in the mouse].
1972-06
[Effect of ethyl alcohol on pharmacokinetics of N,N-dimethyl-dibenzo(b,f)thiepine-10-methylamine-hydrochloride (GP 41 299) in man].
1972-05
Patents

Patents

GB1080979A
2
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:49:32 GMT 2025
Edited
by admin
on Mon Mar 31 17:49:32 GMT 2025
Record UNII
89TLU40RO8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GP-41299
Preferred Name English
DAMOTEPINE HYDROCHLORIDE
Common Name English
DIBENZO(B,F)THIEPIN-10-METHYLAMINE, N,N-DIMETHYL-, HYDROCHLORIDE
Systematic Name English
DIBENZO(B,F)THIEPIN-10-METHANAMINE, N,N-DIMETHYL-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
89TLU40RO8
Created by admin on Mon Mar 31 17:49:32 GMT 2025 , Edited by admin on Mon Mar 31 17:49:32 GMT 2025
PRIMARY
PUBCHEM
11779772
Created by admin on Mon Mar 31 17:49:32 GMT 2025 , Edited by admin on Mon Mar 31 17:49:32 GMT 2025
PRIMARY
CAS
23247-39-4
Created by admin on Mon Mar 31 17:49:32 GMT 2025 , Edited by admin on Mon Mar 31 17:49:32 GMT 2025
PRIMARY
EPA CompTox
DTXSID20945929
Created by admin on Mon Mar 31 17:49:32 GMT 2025 , Edited by admin on Mon Mar 31 17:49:32 GMT 2025
PRIMARY
Related Record Type Details
Structure of DAMOTEPINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DAMOTEPINE
ACTIVE MOIETY
NIH
NCATS
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