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Details

Stereochemistry ACHIRAL
Molecular Formula C17H17NS.ClH
Molecular Weight 303.85
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAMOTEPINE HYDROCHLORIDE

SMILES

Cl.CN(C)CC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2

InChI

InChIKey=OXCDWSYLPNFXHP-UHFFFAOYSA-N
InChI=1S/C17H17NS.ClH/c1-18(2)12-14-11-13-7-3-5-9-16(13)19-17-10-6-4-8-15(14)17;/h3-11H,12H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C17H17NS
Molecular Weight 267.389
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Damotepine is a derivative of thiepin, structurally related to doxepin. Damotepine was discovered by the Swiss pharmaceutical company Geigy A.G. and was evaluated in clinical trials for the treatment of anxiety in the early 1970s.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
[Study on the associated effects of ethyl alcohol and N,N-dimethyl-dibenzo(b,f)thiepin-10-methylamine-hydrochloride (GP 41299) in the mouse].
1972 Jun
[Effect of ethyl alcohol on pharmacokinetics of N,N-dimethyl-dibenzo(b,f)thiepine-10-methylamine-hydrochloride (GP 41 299) in man].
1972 May
Determination of N,N-dimethyldibenzo(b,f)thiepin-10-methylamine by gas-liquid chromatography.
1973 Oct 10
Patents

Patents

GB1080979A
2
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:11:25 GMT 2023
Edited
by admin
on Fri Dec 15 15:11:25 GMT 2023
Record UNII
89TLU40RO8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DAMOTEPINE HYDROCHLORIDE
Common Name English
GP-41299
Code English
DIBENZO(B,F)THIEPIN-10-METHYLAMINE, N,N-DIMETHYL-, HYDROCHLORIDE
Systematic Name English
DIBENZO(B,F)THIEPIN-10-METHANAMINE, N,N-DIMETHYL-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
89TLU40RO8
Created by admin on Fri Dec 15 15:11:25 GMT 2023 , Edited by admin on Fri Dec 15 15:11:25 GMT 2023
PRIMARY
PUBCHEM
11779772
Created by admin on Fri Dec 15 15:11:25 GMT 2023 , Edited by admin on Fri Dec 15 15:11:25 GMT 2023
PRIMARY
CAS
23247-39-4
Created by admin on Fri Dec 15 15:11:25 GMT 2023 , Edited by admin on Fri Dec 15 15:11:25 GMT 2023
PRIMARY
EPA CompTox
DTXSID20945929
Created by admin on Fri Dec 15 15:11:25 GMT 2023 , Edited by admin on Fri Dec 15 15:11:25 GMT 2023
PRIMARY
Related Record Type Details
Structure of DAMOTEPINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DAMOTEPINE
ACTIVE MOIETY
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