MARSTACIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 07:14:44 GMT 2025` Edited by `admin` on `Wed Apr 02 07:14:44 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	0UB3OA67O7
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

PF-06741086

Preferred Name

English

MARSTACIMAB

Official Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN TISSUE FACTOR PATHWAY INHIBITOR) (HUMAN MONOCLONAL PF-06741086 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL PF-06741086 .LAMBDA.-CHAIN, DIMER

Common Name

English

IMMUNOGLOBULIN G1-LAMBDA, ANTI-(HUMAN TISSUE FACTOR PATHWAY INHIBITOR (TFPI, EXTRINSIC PATHWAY INHIBITOR, EPI, LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR, LACI)) HUMAN MONOCLONAL ANTIBODY .GAMMA.1 HEAVY CHAIN (1-449) (HUMAN VH (HOMO SAPIENS IGHV-23*01(

Systematic Name

English

marstacimab [INN]

Common Name

English

MARSTACIMAB [USAN]

Common Name

English

IMMUNOGLOBULIN G1-LAMBDA, ANTI-(HUMAN TISSUE FACTOR PATHWAY INHIBITOR (TFPI, EXTRINSIC PATHWAY INHIBITOR, EPI, LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR, LACI))

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

521916

Created by admin on Wed Apr 02 07:14:44 GMT 2025 , Edited by admin on Wed Apr 02 07:14:44 GMT 2025

Code System Code Type Description

INN

10789

Created by admin on Wed Apr 02 07:14:44 GMT 2025 , Edited by admin on Wed Apr 02 07:14:44 GMT 2025

PRIMARY

SMS_ID

100000177669

Created by admin on Wed Apr 02 07:14:44 GMT 2025 , Edited by admin on Wed Apr 02 07:14:44 GMT 2025

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NCI_THESAURUS

C166436

Created by admin on Wed Apr 02 07:14:44 GMT 2025 , Edited by admin on Wed Apr 02 07:14:44 GMT 2025

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USAN

EF-60

Created by admin on Wed Apr 02 07:14:44 GMT 2025 , Edited by admin on Wed Apr 02 07:14:44 GMT 2025

PRIMARY

FDA UNII

0UB3OA67O7

Created by admin on Wed Apr 02 07:14:44 GMT 2025 , Edited by admin on Wed Apr 02 07:14:44 GMT 2025

PRIMARY

CAS

1985638-39-8

Created by admin on Wed Apr 02 07:14:44 GMT 2025 , Edited by admin on Wed Apr 02 07:14:44 GMT 2025

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From	To
1_22	1_96
1_147	1_203
1_264	1_324
1_370	1_428
1_223	3_217
1_229	2_229
1_232	2_232
2_22	2_96
2_147	2_203
2_264	2_324
2_370	2_428
2_223	4_217
3_22	3_90
3_140	3_199
4_22	4_90
4_140	4_199

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details

Marstacimab-HNCQ

SUB_CONCEPT->SUBSTANCE

Amount:


					E1U4X64NFM

TISSUE FACTOR PATHWAY INHIBITOR

TARGET -> INHIBITOR

Related Record Type Details


					0UB3OA67O7

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL