Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C14H19NO5 |
Molecular Weight | 281.3044 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]1([C@@H](C)O)C(=O)N2C(C(O)=O)=C3[C@H](CCC[C@]3([H])[C@]12[H])OC
InChI
InChIKey=ICFDDEJRXZSWTA-KJFVXYAMSA-N
InChI=1S/C14H19NO5/c1-6(16)9-11-7-4-3-5-8(20-2)10(7)12(14(18)19)15(11)13(9)17/h6-9,11,16H,3-5H2,1-2H3,(H,18,19)/t6-,7+,8+,9-,11-/m1/s1
Molecular Formula | C14H19NO5 |
Molecular Weight | 281.3044 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Sanfetrinem cilexetil (formerly known as GV 118819), a beta-lactam antibiotic, is the oral prodrug of sanfetrinem. Experiments on rodents have revealed that sanfetrinem cilexetil had strong antibacterial activity in vitro and good pharmacokinetic behavior in mice. This drug was suitable for the treatment of infections caused by a variety of bacteria and participated in a phase II clinical trial. However, this study was discontinued.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
In vivo antibacterial activities of sanfetrinem cilexetil, a new oral tricyclic antibiotic. | 1998 Jul |
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In-vitro activity of sanfetrinem against isolates of Streptococcus pneumoniae and Staphylococcus aureus. | 1998 Nov |
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Carboxylesterases, a key factor in evaluating potential genotoxicity of Trinem antibiotics. | 2000 Jan |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8950528
The activity of sanfetrinem was determined using a broth microdilution MIC method versus a large number of clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis obtained in a recent 30-center United States surveillance study. The sanfetrinem MIC50 and MIC90 values for these three organism groups were 0.015 and 0.5 microgram/ml, 0.25, and 0.5 microgram/ml, and 0.015 and 0.03, respectively.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:26:06 GMT 2023
by
admin
on
Sat Dec 16 17:26:06 GMT 2023
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Record UNII |
0S36458I44
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Record Status |
Validated (UNII)
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Record Version |
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-
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Official Name | English | ||
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Common Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C260
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admin on Sat Dec 16 17:26:07 GMT 2023 , Edited by admin on Sat Dec 16 17:26:07 GMT 2023
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Code System | Code | Type | Description | ||
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CHEMBL316197
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7291
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C104757
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100000084052
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CHEMBL2107073
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156769-21-0
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C73825
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0S36458I44
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71452
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SUB10441MIG
Created by
admin on Sat Dec 16 17:26:07 GMT 2023 , Edited by admin on Sat Dec 16 17:26:07 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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TARGET ORGANISM->INHIBITOR |
MIC90
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TARGET ORGANISM->INHIBITOR |
MIC90
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SALT/SOLVATE -> PARENT |
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TARGET ORGANISM->INHIBITOR |
MIC90
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TARGET ORGANISM->INHIBITOR |
MIC90
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Related Record | Type | Details | ||
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PRODRUG -> METABOLITE ACTIVE |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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