DAXALIPRAM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H19NO4
Molecular Weight	265.305
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCOC1=C(OC)C=CC(=C1)[C@]2(C)CNC(=O)O2

InChI

InChIKey=PCCPERGCFKIYIS-AWEZNQCLSA-N

InChI=1S/C14H19NO4/c1-4-7-18-12-8-10(5-6-11(12)17-3)14(2)9-15-13(16)19-14/h5-6,8H,4,7,9H2,1-3H3,(H,15,16)/t14-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C14H19NO4
Molecular Weight	265.305
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15576036

Daxalipram is a selective inhibitor of phosphodiesterase (PDE) 4B.This compound is an R-isomer of mesopram and is known as (R)-mesopram. Mesopram is known to trigger ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo. Moreover, is used in compositions for the treatment or prevention of respiratory inflammation.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cAMP-specific 3',5'-cyclic phosphodiesterase 4B 5 Target ID: Q07343 Gene ID: 5142.0 Gene Symbol: PDE4B Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15576036	Inhibitor 8228

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2565

PubMed

Title	Date	PubMed
Structural basis for the activity of drugs that inhibit phosphodiesterases.	2004 Dec	15576036

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:43:26 UTC 2023` Edited by `admin` on `Wed Jul 05 23:43:26 UTC 2023`
Record UNII	0RB5T277IY
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DAXALIPRAM

Official Name

English

ZK-117137

Code

English

ZK117137

Code

English

Mesopram

Common Name

English

(5R)-5-(4-METHOXY-3-PROPOXYPHENYL)-5-METHYL-1,3-OXAZOLIDIN-2-ONE

Systematic Name

English

daxalipram [INN]

Common Name

English

Daxalipram [WHO-DD]

Common Name

English

SH-636

Code

English

SH636

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C744