FAZADINIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H24N6
Molecular Weight	444.5304
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(N(\N=N\N2C3=[N+](C=CC=C3)C(C)=C2C4=CC=CC=C4)C5=[N+]1C=CC=C5)C6=CC=CC=C6

InChI

InChIKey=NJAGGYXZTILBMJ-QVIHXGFCSA-N

InChI=1S/C28H24N6/c1-21-27(23-13-5-3-6-14-23)33(25-17-9-11-19-31(21)25)29-30-34-26-18-10-12-20-32(26)22(2)28(34)24-15-7-4-8-16-24/h3-20H,1-2H3/q+2/b30-29+

HIDE SMILES / InChI

Molecular Formula	C28H24N6
Molecular Weight	444.5304
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6113885

Fazadinium (used as a bromide salt) is a muscle relaxant, which was applied in anesthesia under the name Fazadon. The current marketing status is unknown and the drug is supposed to be discontinued.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skeletal muscle relaxation 17 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6136134	Primary		Approved 8583	FAZADON Approved Use Muscle relaxant in anesthesia.

T_1/2

Value	Dose	Co-administered	Analyte	Population
82 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6107098/	1 mg/kg single, intravenous dose: 1 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: THIOPENTAL SODIUM	THIOPENTAL SODIUM	FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
153 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6107098/	1 mg/kg single, intravenous dose: 1 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: THIOPENTAL SODIUM	THIOPENTAL SODIUM	FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
103 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6107098/	1 mg/kg single, intravenous dose: 1 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: THIOPENTAL SODIUM	THIOPENTAL SODIUM	FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
30.2 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6108730/	0.5 mg/kg single, intravenous dose: 0.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
50.1 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6108730/	1 mg/kg single, intravenous dose: 1 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
76.4 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6108730/ \| https://pubmed.ncbi.nlm.nih.gov/28133/	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
85 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/42420/	1 mg/kg single, intravenous dose: 1 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: THIOPENTAL SODIUM	THIOPENTAL SODIUM	FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
140 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/42420/	1 mg/kg single, intravenous dose: 1 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: THIOPENTAL SODIUM	THIOPENTAL SODIUM	FAZADINIUM plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
49% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6122460/			FAZADINIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
43% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6122460/			FAZADINIUM serum	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
1.5 mg/kg single, intravenous Highest studied dose Dose: 1.5 mg/kg Route: intravenous Route: single Dose: 1.5 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/6113885/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6113885/	Sources: https://pubmed.ncbi.nlm.nih.gov/6113885/
37 mg single, intravenous Studied dose Dose: 37 mg Route: intravenous Route: single Dose: 37 mg Sources: https://pubmed.ncbi.nlm.nih.gov/42323/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/42323/	Other AEs: Death... Other AEs: Death (grade 5) Sources: https://pubmed.ncbi.nlm.nih.gov/42323/
45 mg single, intravenous Studied dose Dose: 45 mg Route: intravenous Route: single Dose: 45 mg Sources: https://pubmed.ncbi.nlm.nih.gov/6124175/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6124175/	Other AEs: Cardiovascular collapse... Other AEs: Cardiovascular collapse Sources: https://pubmed.ncbi.nlm.nih.gov/6124175/

AEs

AE	Significance	Dose	Population
Death	grade 5	37 mg single, intravenous Studied dose Dose: 37 mg Route: intravenous Route: single Dose: 37 mg Sources: https://pubmed.ncbi.nlm.nih.gov/42323/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/42323/
Cardiovascular collapse		45 mg single, intravenous Studied dose Dose: 45 mg Route: intravenous Route: single Dose: 45 mg Sources: https://pubmed.ncbi.nlm.nih.gov/6124175/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6124175/

PubMed

Title	Date	PubMed
Post-suxamethonium pains in Nigerian surgical patients.	1982-02	7176945
Effect of fazadinium (Fazadon) on muscle fasciculations induced by succinylcholine.	1981-09	6116533
Adverse reactions following fazadinium-thiopentone induction.	1979-07-01	42323

Sample Use Guides

In Vivo Use Guide

The recommended dose is 1.5 mg/kg.

Route of Administration: Intravenous

In Vitro Use Guide

The guinea-pig isolated hypogastric nerve-vas deferens preparation and isolated phrenic nerve-diaphragm preparation were incubated with fazadinium at a concentration from 10(-5) to 3.2*10(-4) M. EC50 for neuromuscular blockade was 2.8*10(-5) M and EC50 for ganglion blockade was 6.4*10(-5) M.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:19:22 GMT 2025` Edited by `admin` on `Mon Mar 31 18:19:22 GMT 2025`
Record UNII	0R97XIX3OA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FAZADINIUM

Common Name

English

DAZOPIRONIUM

Preferred Name

English

FAZADINIUM CATION

Common Name

English

1,1'-AZOBIS(3-METHYL-2-PHENYL-1H-IMIDAZO(1,2-A)PYRIDIN-4-IUM)

Systematic Name

English

FAZADINIUM ION

Common Name

English

Fazadinium [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696