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Details

Stereochemistry ACHIRAL
Molecular Formula C28H24N6
Molecular Weight 444.5304
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 2

SHOW SMILES / InChI
Structure of FAZADINIUM

SMILES

CC1=C(N(\N=N\N2C3=[N+](C=CC=C3)C(C)=C2C4=CC=CC=C4)C5=[N+]1C=CC=C5)C6=CC=CC=C6

InChI

InChIKey=NJAGGYXZTILBMJ-QVIHXGFCSA-N
InChI=1S/C28H24N6/c1-21-27(23-13-5-3-6-14-23)33(25-17-9-11-19-31(21)25)29-30-34-26-18-10-12-20-32(26)22(2)28(34)24-15-7-4-8-16-24/h3-20H,1-2H3/q+2/b30-29+

HIDE SMILES / InChI

Molecular Formula C28H24N6
Molecular Weight 444.5304
Charge 2
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Fazadinium (used as a bromide salt) is a muscle relaxant, which was applied in anesthesia under the name Fazadon. The current marketing status is unknown and the drug is supposed to be discontinued.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
FAZADON

PubMed

Sample Use Guides

In Vivo Use Guide
The recommended dose is 1.5 mg/kg.
Route of Administration: Intravenous
In Vitro Use Guide
The guinea-pig isolated hypogastric nerve-vas deferens preparation and isolated phrenic nerve-diaphragm preparation were incubated with fazadinium at a concentration from 10(-5) to 3.2*10(-4) M. EC50 for neuromuscular blockade was 2.8*10(-5) M and EC50 for ganglion blockade was 6.4*10(-5) M.
Substance Class Chemical
Record UNII
0R97XIX3OA
Record Status Validated (UNII)
Record Version