FAZADINIUM BROMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H24N6.2Br
Molecular Weight	604.338
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].[Br-].CC1=C(N(\N=N\N2C3=[N+](C=CC=C3)C(C)=C2C4=CC=CC=C4)C5=[N+]1C=CC=C5)C6=CC=CC=C6

InChI

InChIKey=LBOZSXSPRGACHC-NFOZGECASA-L

InChI=1S/C28H24N6.2BrH/c1-21-27(23-13-5-3-6-14-23)33(25-17-9-11-19-31(21)25)29-30-34-26-18-10-12-20-32(26)22(2)28(34)24-15-7-4-8-16-24;;/h3-20H,1-2H3;2*1H/q+2;;/p-2/b30-29+;;

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C28H24N6
Molecular Weight	444.5304
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6113885

Fazadinium (used as a bromide salt) is a muscle relaxant, which was applied in anesthesia under the name Fazadon. The current marketing status is unknown and the drug is supposed to be discontinued.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skeletal muscle relaxation 17 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6136134	Primary		Approved 8429	FAZADON Approved Use Muscle relaxant in anesthesia.

PubMed

Title	Date	PubMed
Adverse reactions following fazadinium-thiopentone induction.	1979 Jul-Aug	42323
Effect of fazadinium (Fazadon) on muscle fasciculations induced by succinylcholine.	1981 Sep	6116533
Post-suxamethonium pains in Nigerian surgical patients.	1982 Feb	7176945

Sample Use Guides

In Vivo Use Guide

The recommended dose is 1.5 mg/kg.

Route of Administration: Intravenous

In Vitro Use Guide

The guinea-pig isolated hypogastric nerve-vas deferens preparation and isolated phrenic nerve-diaphragm preparation were incubated with fazadinium at a concentration from 10(-5) to 3.2*10(-4) M. EC50 for neuromuscular blockade was 2.8*10(-5) M and EC50 for ganglion blockade was 6.4*10(-5) M.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:36:02 GMT 2023` Edited by `admin` on `Fri Dec 15 17:36:02 GMT 2023`
Record UNII	8WV5538LFK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FAZADINIUM BROMIDE

Official Name

English

FAZADINIUM BROMIDE [MI]

Common Name

English

Fazadinium bromide [WHO-DD]

Common Name

English

AH-8165D

Code

English

FAZADINIUM BROMIDE [MART.]

Common Name

English

AH 8165D

Code

English

1,1'-AZOBIS(3-METHYL-2-PHENYL-1H-IMIDAZO(1,2-A)PYRIDIN-4-IUM) DIBROMIDE

Systematic Name

English

fazadinium bromide [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM03AC08