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Details

Stereochemistry ACHIRAL
Molecular Formula C28H24N6.2Br
Molecular Weight 604.338
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FAZADINIUM BROMIDE

SMILES

[Br-].[Br-].CC1=C(N(\N=N\N2C3=[N+](C=CC=C3)C(C)=C2C4=CC=CC=C4)C5=[N+]1C=CC=C5)C6=CC=CC=C6

InChI

InChIKey=LBOZSXSPRGACHC-NFOZGECASA-L
InChI=1S/C28H24N6.2BrH/c1-21-27(23-13-5-3-6-14-23)33(25-17-9-11-19-31(21)25)29-30-34-26-18-10-12-20-32(26)22(2)28(34)24-15-7-4-8-16-24;;/h3-20H,1-2H3;2*1H/q+2;;/p-2/b30-29+;;

HIDE SMILES / InChI

Molecular Formula BrH
Molecular Weight 80.912
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C28H24N6
Molecular Weight 444.5304
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Fazadinium (used as a bromide salt) is a muscle relaxant, which was applied in anesthesia under the name Fazadon. The current marketing status is unknown and the drug is supposed to be discontinued.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
FAZADON

Approved Use

Muscle relaxant in anesthesia.
PubMed

PubMed

TitleDatePubMed
Adverse reactions following fazadinium-thiopentone induction.
1979 Jul-Aug
Effect of fazadinium (Fazadon) on muscle fasciculations induced by succinylcholine.
1981 Sep
Post-suxamethonium pains in Nigerian surgical patients.
1982 Feb

Sample Use Guides

The recommended dose is 1.5 mg/kg.
Route of Administration: Intravenous
In Vitro Use Guide
The guinea-pig isolated hypogastric nerve-vas deferens preparation and isolated phrenic nerve-diaphragm preparation were incubated with fazadinium at a concentration from 10(-5) to 3.2*10(-4) M. EC50 for neuromuscular blockade was 2.8*10(-5) M and EC50 for ganglion blockade was 6.4*10(-5) M.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:36:02 UTC 2023
Edited
by admin
on Fri Dec 15 17:36:02 UTC 2023
Record UNII
8WV5538LFK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FAZADINIUM BROMIDE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
FAZADINIUM BROMIDE [MI]
Common Name English
Fazadinium bromide [WHO-DD]
Common Name English
AH-8165D
Code English
FAZADINIUM BROMIDE [MART.]
Common Name English
AH 8165D
Code English
1,1'-AZOBIS(3-METHYL-2-PHENYL-1H-IMIDAZO(1,2-A)PYRIDIN-4-IUM) DIBROMIDE
Systematic Name English
fazadinium bromide [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QM03AC08
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
NCI_THESAURUS C66886
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
WHO-ATC M03AC08
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
Code System Code Type Description
DRUG BANK
DB13745
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
ChEMBL
CHEMBL1739746
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
PUBCHEM
6321422
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
CAS
49564-56-9
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
WIKIPEDIA
FAZADINIUM BROMIDE
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
SMS_ID
100000081765
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
MERCK INDEX
m5250
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY Merck Index
FDA UNII
8WV5538LFK
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
NCI_THESAURUS
C80530
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
ECHA (EC/EINECS)
256-378-4
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
EPA CompTox
DTXSID4023040
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
EVMPD
SUB07516MIG
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
INN
3678
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
MESH
C084773
Created by admin on Fri Dec 15 17:36:02 UTC 2023 , Edited by admin on Fri Dec 15 17:36:02 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY