IMIRESTAT

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H8F2N2O2
Molecular Weight	286.233
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC2=C(C=C1)C3=C(C=C(F)C=C3)C24NC(=O)NC4=O

InChI

InChIKey=QCCHBHSAIQIQGO-UHFFFAOYSA-N

InChI=1S/C15H8F2N2O2/c16-7-1-3-9-10-4-2-8(17)6-12(10)15(11(9)5-7)13(20)18-14(21)19-15/h1-6H,(H2,18,19,20,21)

HIDE SMILES / InChI

Molecular Formula	C15H8F2N2O2
Molecular Weight	286.233
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1495891 | https://www.ncbi.nlm.nih.gov/pubmed/2127314 | https://www.ncbi.nlm.nih.gov/pubmed/2106677

Imirestat is an aldose reductase inhibitor patented by global medical company Alcon Laboratories for the late complications of diabetes.

Originator

Approval Year

PubMed

Title	Date	PubMed
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition.	1992 Mar 30	1374869
Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies.	2006 Jul	16614166

Patents

Sample Use Guides

In Vivo Use Guide

single doses of 20 to 50 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:51:10 GMT 2023` Edited by `admin` on `Fri Dec 15 15:51:10 GMT 2023`
Record UNII	0PM69S95UQ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IMIRESTAT

Official Name

English

AL-1576

Code

English

HOE-843

Code

English

imirestat [INN]

Common Name

English

2,7-DIFLUOROSPIRO(FLUORENE-9,4'-IMIDAZOLIDINE)-2',5'-DIONE

Systematic Name

English

HOE 843

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C72880